NCT03484299RecruitingPhase 1
Chemotherapy and Irreversible Electroporation in the Treatment of Advanced Pancreatic Adenocarcinoma
Chemotherapy and Irreversible Electroporation (IRE) in the Treatment of Advanced Pancreatic Adenocarcinoma
Source: ClinicalTrials.gov · Last updated 29 Oct 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Compare the efficacy and tolerability of IRE in combination with either FOLFIRINOX or gemcitabine in patients with locally advanced pancreatic cancer.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 13 Feb 2018
- Start date
- 30 May 2018
- Primary completion date
- 31 Jul 2026
- Lead sponsor
- University of Louisville
- Diseases
- Pancreatic cancer
- NCT number
- NCT03484299
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 20
- From 30 May 2018 to the primary completion date, 31 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- have non-removable implants with metal parts within 1 cm of the target lesion
- had a myocardial infarction within 3 months prior to enrollment
Other illness
- participating in another clinical trial for the treatment of cancer at the time of screening
- have a cardiac pacemaker or ICD implanted that cannot be deactivated during IRE procedure
Other
- pregnant or currently breast feeding
Who the study is looking for
- greater than or equal to 18 years of age
- diagnosed with stage III pancreatic cancer
- tumor is measurable
- GFR \> mL/min/1.73m2
- willing and able to comply with protocol requirements
- AST/ALT \>3 times upper limit of normal
- stable surgical post-operative course as defined by operative surgeon
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Louisville Coordinator of this site? Confirm its status | Louisville | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.