NCT03491176Active, not recruiting
Magnetic Resonance (MR) Imaging & Blood Biomarkers for Head and Neck Cancer
Quantification of Tumor Imaging Kinetics and Blood Biomarkers in Head and Neck Cancer Patients
Source: ClinicalTrials.gov · Last updated 20 May 2026
Brief summary (registry, in English)
The goal of this research study is to find out if using additional MRIs and biomarker testing can help researchers learn to predict how the tumor may change during radiation therapy. Biomarkers are found in the blood/tissue and may be related to participant's reaction to treatment. Biomarker testing in the study may include genetic biomarkers. This is an investigational study. MRIs on this study are performed using FDA-approved and commercially available methods. Having added scans and blood tests is investigational. Up to 100 participants will be enrolled in this study (up to 80 patients and up to 20 healthy volunteers in another part of the study). All will take part at MD Anderson.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 23 Mar 2018
- Start date
- 18 May 2017
- Primary completion date
- 31 Oct 2027
- Lead sponsor
- M.D. Anderson Cancer Center
- Diseases
- Head and neck cancer
- NCT number
- NCT03491176
What you commit to
- Study type: Observational
- Planned participants: 100
- From 18 May 2017 to the primary completion date, 31 Oct 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous radiation treatment for head and neck mucosal primary cancers within the past 5 years (i.e. oropharynx, nasopharynx, hypopharynx, larynx, and oral cavity)
Other illness
- History of claustrophobia
Other
- Pregnant or breast-feeding females
- Contraindications to magnetic resonance (MR) imaging (e.g. implanted metallic prostheses, defibrillators, or stimulators)
- Contraindications to gadolinium contrast (e.g. kidney dysfunction)
Who the study is looking for
- Biopsy proven diagnosis of squamous cell carcinoma (SCC) of head and neck mucosa. Clinical evidence should be documented, and may consist of imaging, endoscopic evaluation, palpation, and should be sufficient to estimate the size of the primary for purposes of T staging
- No distant metastases, based on routine staging workup
- Consent for blood collection for biomarker analysis
- No head and neck surgery of the primary tumor or lymph nodes except for incisional or excisional biopsies
- Eastern Cooperative Oncology Group (ECOG) = 0, 1, or 2
- Dispositioned to curative intent radiotherapy
- For females of child-bearing age, a negative pregnancy test
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| M D Anderson Cancer Center Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.