NCT03534934Completed
CT-Based Modeling of Bone Micro-Architecture and Fracture-Risk in COPD
Source: ClinicalTrials.gov · Last updated 28 Jan 2026
Brief summary (registry, in English)
The goal of this translational study is to establish a newly emerging CT-based tool for the characterization of changes in bone micro-architecture and assessment of their implications for fracture-risk in a population of COPD patients at risk for osteoporosis. The tool will be suitable and generalizable across emerging CT scanners from different vendors, and it will provide a more structurally-based assessment of osteoporosis and bone loss than is provided by simple bone density measures. The study will characterize the impact of different COPD-related factors on bone structure, and their implications for fracture-risk, leading to the development of a COPD-specific model for assessment of fracture-risk that will utilize patient-specific demographic, clinical and radiographic data, and CT BMD at the spine, as well as bone structural measures at the hip and/or ankle.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 560 (actual)
- First submitted
- 16 Apr 2018
- Start date
- 26 Feb 2019
- Primary completion date
- 19 Mar 2025
- Lead sponsor
- Punam K Saha
- Diseases
- COPD, Osteoporosis
- NCT number
- NCT03534934
What you commit to
- Study type: Interventional
- Participants enrolled: 560
- From 26 Feb 2019 to the primary completion date, 19 Mar 2025
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently receiving dialysis
- Any lower extremity fracture with hardware implant(s)
Other illness
- Metastatic Malignancy
- History of bilateral tibia fractures
Other
- Pregnant or breast-feeding
- Any lower extremity fracture within the last year
Who the study is looking for
- Current or former smoker, defined as having at least 10-pack year lifetime history
- Age: 45-90
- Subjects will be stratified into groups based on COPD disease status: smokers with COPD and smokers without COPD.
- Smokers with COPD will be further stratified into three groups: low emphysema (\< 3%), moderate emphysema (between 3 and 10%), and severe emphysema (\> 10%).
Age in the registry: 45 years to 90 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Iowa Hospitals and Clinics Coordinator of this site? Confirm its status | Iowa City | United States | Unknown status |
| Columbia University Medical Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.