NCT03554174Active, not recruitingPhase 1
Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder
Source: ClinicalTrials.gov · Last updated 5 Nov 2026
Brief summary (registry, in English)
The primary goal of this pilot study is to investigate whether psilocybin alters neuroplasticity in people with major depressive disorder. The primary hypothesis is that psilocybin will result in neuroplastic changes that parallel improvement in symptoms of depression.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 18 (estimated)
- First submitted
- 13 Apr 2018
- Start date
- 27 Feb 2018
- Primary completion date
- 8 Jul 2021
- Lead sponsor
- Yale University
- Diseases
- Depression
- NCT number
- NCT03554174
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 18
- From 27 Feb 2018 to the primary completion date, 8 Jul 2021
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently taking a conventional antidepressant medication
- Urine toxicology positive to drugs of abuse on experimental test days
Other illness
- Axis I psychotic disorder (e.g. schizophrenia, bipolar I, depression with psychosis)
- Axis I psychotic disorder in first degree relative
- Unstable medical or neurological conditions
- Significant cognitive disorders
- History of intolerance to drugs known to significantly alter perception e.g., psilocybin, LSD, salvinorin A, mescaline, etc.
Other
- Pregnant, breastfeeding, lack of adequate birth control
Who the study is looking for
- Diagnosed with Major Depressive Disorder (MDD), single or recurrent episode, and currently experiencing a Major Depressive Episode (MDE)
- Failed to achieve a satisfactory clinical response to at least one adequate antidepressant trial during the current depressive episode
- Currently engaged in treatment with a mental health clinician
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| VA Connecticut Healthcare System, West Haven Campus Coordinator of this site? Confirm its status | West Haven | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.