NCT03558789Completed
Metallic Taste Before, During and After Treatment of Head and Neck Cancer
Metallic Taste Before, During and After Treatment of Head and Neck Cancer : Etiologies and Impact on Quality of Life
Source: ClinicalTrials.gov · Last updated 8 Sept 2025
Brief summary (registry, in English)
Metallic taste in head and neck cancer is widely under-estimated in the literature. Its causes are multiple and poorly defined. Though it has a strong impact on the nutritional status. The main objective of the TORCAD project is to test the hypothesis that intraoral lipoperoxidation is associated to metallic taste onset before, during and after treatment of head and neck cancer (HNC). The secondary goals are to evaluate the involvement of others physiopathological factors in metallic taste: (i) additional chemical modification in the saliva; (ii) release of inhibition of the facial nerve on the glossopharyngeal nerve; presence of an intraoral electric current; food pleasantness and acceptability; quality of life.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 100 (actual)
- First submitted
- 26 Apr 2018
- Start date
- 26 Apr 2018
- Primary completion date
- 1 Dec 2022
- Lead sponsor
- Centre Hospitalier de Valence
- Diseases
- Head and neck cancer
- NCT number
- NCT03558789
What you commit to
- Study type: Observational
- Participants enrolled: 100
- From 26 Apr 2018 to the primary completion date, 1 Dec 2022
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of cancer (head and neck or other) that could be a confounding factor (dysgeusia, dysosmia, salivary composition disorder)
- Early cancer recurrence (\< 6 months after the end of the last treatment) because the taste, smell, and/or composition of the saliva can be altered by the cancer itself
Other
- Pregnant woman (frequent dysgeusia and dysosmia)
- Total laryngectomy (treatment-induced hyposmia)
- Persons deprived of liberty, under guardianship or under curatorship or unable to submit to the medical follow-up of the test for geographical, social or psychic reasons
Who the study is looking for
- Any head and neck cancer
- Before any treatment and treatment (surgery, chemotherapy, radiation therapy)
- Before the appearance of the metallic taste symptom
- Age ≥ 18 years
- Estimated life expectancy ≥ 6 months.
- Affiliation to a Social security system
- Patient who has given written consent signed before any specific procedure of the protocol
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CH Valence Coordinator of this site? Confirm its status | Valence | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.