NCT03558893Completed
Sleep and Circadian Mechanisms of Non-dipping Blood Pressure
Sleep and Circadian Mechanisms Contributing to Nocturnal Non-dipping Blood Pressure
Source: ClinicalTrials.gov · Last updated 20 Jul 2026
Brief summary (registry, in English)
This study will be the first to distinguish the relative contributions of sleep, circadian and behavioral mechanisms to the non-dipping BP profile in Black adults and will lay the groundwork for optimizing therapies dependent on mechanisms, such as targeting sleep, targeting circadian rhythmicity, or targeting behaviors, and raising the possibility that ideal therapy for hypertension (HTN) may differ by race. This research will ultimately help to improve health and survival in black populations with HTN.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 30 (actual)
- First submitted
- 5 Jun 2018
- Start date
- 1 Dec 2018
- Primary completion date
- 31 Dec 2024
- Lead sponsor
- Oregon Health and Science University
- Diseases
- High blood pressure
- NCT number
- NCT03558893
What you commit to
- Study type: Interventional
- Participants enrolled: 30
- From 1 Dec 2018 to the primary completion date, 31 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently treated with pharmacologic agents for hypertension
- Regular night work or rotating shift work for the three months prior to the study
- Travel across more than three time zones during the three months prior to the study.
Other illness
- Any acute, chronic or debilitating medical conditions, other than mild hypertension (140\<SBP\<160 or 90\<DBP\<100 mmHg) and severe renal disease (glomerular filtration rate \<30)
- History of severe psychiatric illnesses or psychiatric disorders will be excluded, including alcoholism, drug dependency, major depression, manic depressive illness, schizophrenic disorders, panic disorder, generalized anxiety disorder, post-traumatic stress disorder, agoraphobia, claustrophobia, paranoid personality disorder, schizoid personality disorder, schizotypal personality disorder, borderline personality disorder, and antisocial personality disorder.
Other
- Blood pressure \>160/100 mmHg
- Smoked within the last year
- Moderate to severe obstructive sleep apnea (OSA)
Who the study is looking for
- Self-identified Black or White
- 'normotensive' (resting systolic blood pressure (SBP) \<140/90 mmHg) or uncomplicated stage 1 'hypertensive' (systolic BP between 140 and 160 mmHg or a diastolic (DBP) between 90 and 100 mmHg).
- free of all prescription and non-prescription drugs (including caffeine, nicotine, alcohol and herbal medications)
Age in the registry: 30 years to 60 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Oregon Health Science University Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.