NCT03573089Recruiting
Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)
An Investigator-initiated, International, Multi-centre, Prospective, Randomized, Open-label, Parallel-group, Superiority, and Pragmatic Large Simple Trial (LST) to Determine Whether the Currently Recommended Strategy of Intensive Reduction of Serum Phosphate Concentration Towards the Normal Level Results in Significant Patient-centred Benefits in End-stage Kidney Disease (ESKD) Patients Receiving Dialysis.
Source: ClinicalTrials.gov · Last updated 26 Aug 2026
Brief summary (registry, in English)
During end-stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-centred outcomes has never been tested. This trial will evaluate whether compared to high levels, lowering blood phosphate levels would reduce death or major events due to heart disease, improve physical health, and be cost-effective.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 3600 (estimated)
- First submitted
- 20 May 2018
- Start date
- 10 Dec 2019
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- The University of Queensland
- Diseases
- Chronic kidney disease
- NCT number
- NCT03573089
What you commit to
- Study type: Interventional
- Planned participants: 3600
- From 10 Dec 2019 to the primary completion date, 31 Dec 2027
- 126 sites in 9 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Elective kidney transplantation scheduled,
- Concomitant major illness / comorbidity that may result in death in the next 6 months in the view of the treating physician,
Lab values
- Participation in an interventional study that is likely to affect serum phosphate concentration.
Who the study is looking for
- Age ≥45 years, or Age ≥18 years with diabetes,
- ESKD on haemodialysis or peritoneal dialysis, for at least 3 months,
- Currently prescribed at least one phosphate-lowering medication at any dose
- Able to provide informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (126)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Central and Northern Adelaide Renal and Transplant Service Coordinator of this site? Confirm its status | Adelaide | Australia | Completed |
| Armadale Hospital Coordinator of this site? Confirm its status | Armadale | Australia | Completed |
| Flinders Medical Centre Coordinator of this site? Confirm its status | Bedford Park | Australia | Completed |
| Sunshine Coast University Hospital Coordinator of this site? Confirm its status | Birtinya | Australia | Completed |
| Royal Brisbane and Women's Hospital Coordinator of this site? Confirm its status | Brisbane | Australia | Completed |
| Princess Alexandra Hospital Coordinator of this site? Confirm its status | Brisbane | Australia | Completed |
| Bundaberg Hospital Coordinator of this site? Confirm its status | Bundaberg | Australia | Completed |
| Cairns Hospital Coordinator of this site? Confirm its status | Cairns | Australia | Completed |
| Royal Prince Alfred Hosptial Coordinator of this site? Confirm its status | Camperdown | Australia | Completed |
| Austin Health Coordinator of this site? Confirm its status | Heidelberg | Australia | Completed |
| Fraser Coast Renal Service Coordinator of this site? Confirm its status | Hervey Bay | Australia | Completed |
| Nepean Hospital Coordinator of this site? Confirm its status | Kingswood | Australia | Completed |
| St George Hospital Coordinator of this site? Confirm its status | Kogarah | Australia | Completed |
| Mackay Hospital Coordinator of this site? Confirm its status | Mackay | Australia | Completed |
| Logan Hospital Coordinator of this site? Confirm its status | Meadowbrook | Australia | Completed |
| Royal Melbourne Hospital Coordinator of this site? Confirm its status | Melbourne | Australia | Completed |
| St Vincent's Hospital Melbourne Coordinator of this site? Confirm its status | Melbourne | Australia | Completed |
| Royal North Shore Hospital Coordinator of this site? Confirm its status | Saint Leonards | Australia | Completed |
| Gold Coast University Hospital Coordinator of this site? Confirm its status | Southport | Australia | Completed |
| Townsville University Hospital Coordinator of this site? Confirm its status | Townsville | Australia | Completed |
| Latrobe Regional Hospital Coordinator of this site? Confirm its status | Traralgon | Australia | Completed |
| Western Sydney Renal Service Coordinator of this site? Confirm its status | Westmead | Australia | Completed |
| Wollongong Hospital Coordinator of this site? Confirm its status | Wollongong | Australia | Completed |
| Fundacao Felice Rosso - Hospital Felicio Rocho Coordinator of this site? Confirm its status | Barro Preto | Brazil | Recruiting |
| Sociedade Hospitalar Angelina Caron Coordinator of this site? Confirm its status | Campina Grande | Brazil | Recruiting |
| BRA Santa Casa de Misericórdia de Ponta Grossa Coordinator of this site? Confirm its status | Ponta Grossa | Brazil | Recruiting |
| Hospital de Clinicas Porto Alegre Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Recruiting |
| Hospital Alemão Oswaldo Cruz Coordinator of this site? Confirm its status | São Paulo | Brazil | Recruiting |
| Serviço Ubaense de Nefrologia Ltda Coordinator of this site? Confirm its status | Ubá | Brazil | Recruiting |
| Foothills Hospital/ U of Calgary Coordinator of this site? Confirm its status | Calgary | Canada | Recruiting |
| Alberta Health Services Coordinator of this site? Confirm its status | Edmonton | Canada | Recruiting |
| Dalhousie University Coordinator of this site? Confirm its status | Halifax | Canada | Recruiting |
| Queen's University Coordinator of this site? Confirm its status | Kingston | Canada | Recruiting |
| London Health Sciences Centre Coordinator of this site? Confirm its status | London | Canada | Recruiting |
| The Charles Lemoyne Hospital Coordinator of this site? Confirm its status | Longueuil | Canada | Recruiting |
| CHUM Coordinator of this site? Confirm its status | Montreal | Canada | Recruiting |
| Jewish General Hospital Coordinator of this site? Confirm its status | Montreal | Canada | Recruiting |
| McGill University Health Centre Coordinator of this site? Confirm its status | Montreal | Canada | Recruiting |
| Sacre Coeur Hospital Coordinator of this site? Confirm its status | Montreal | Canada | Recruiting |
| Hôpital Maisonneuve-Rosemont Coordinator of this site? Confirm its status | Montreal | Canada | Recruiting |
| Sunnybrook Health Sciences Centre Coordinator of this site? Confirm its status | North York | Canada | Recruiting |
| Oakville Trafalgar Memorial Hospital Coordinator of this site? Confirm its status | Oakville | Canada | Recruiting |
| Orillia Soldier's Memorial Hospital Coordinator of this site? Confirm its status | Orillia | Canada | Recruiting |
| Lakeridge Health Coordinator of this site? Confirm its status | Oshawa | Canada | Recruiting |
| The Ottawa Hospital Coordinator of this site? Confirm its status | Ottawa | Canada | Recruiting |
| CHU de Quebec-Universite Laval Coordinator of this site? Confirm its status | Québec | Canada | Recruiting |
| Red Deer Hospital; Coordinator of this site? Confirm its status | Red Deer | Canada | Recruiting |
| Prairie Vascular Research Inc. Coordinator of this site? Confirm its status | Regina | Canada | Recruiting |
| Mackenzie Health Coordinator of this site? Confirm its status | Richmond Hill | Canada | Recruiting |
| Scarborough Hospital Network Coordinator of this site? Confirm its status | Scarborough Village | Canada | Recruiting |
| Centre hospitalier universitaire de Sherbrooke (CHUS) Coordinator of this site? Confirm its status | Sherbrooke | Canada | Recruiting |
| Centre Hospitalier Universitaire de Sherbrooke Coordinator of this site? Confirm its status | Sherbrooke | Canada | Recruiting |
| Humber River Hospital Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
| St. Joseph's Healthcare Hamilton Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
| Michael Garron Hospital Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
| Trillium Health Partners Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
| St. Joseph's Healthcare Toronto Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
| University Health Network - University of Toronto Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
| St. Michael's Hospital Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
| St. Paul's Hospital Coordinator of this site? Confirm its status | Vancouver | Canada | Recruiting |
| Vancouver General Hospital Coordinator of this site? Confirm its status | Vancouver | Canada | Completed |
| St. Boniface General Hospital Coordinator of this site? Confirm its status | Winnipeg | Canada | Recruiting |
| AURA Paris - Plaisance Coordinator of this site? Confirm its status | Paris | France | Recruiting |
| NHS Lanarkshire Coordinator of this site? Confirm its status | Airdrie | United Kingdom | Recruiting |
| Wirral University Teaching Hospital NHS Foundation Trust Coordinator of this site? Confirm its status | Birkenhead | United Kingdom | Recruiting |
| University Hospital Birmingham NHS Foundation Trust Coordinator of this site? Confirm its status | Birmingham | United Kingdom | Recruiting |
| Bradford Teaching Hospital NHS Foundation Trust Coordinator of this site? Confirm its status | Bradford | United Kingdom | Recruiting |
| University Hospitals Sussex NHS Foundation Trust Coordinator of this site? Confirm its status | Brighton | United Kingdom | Recruiting |
| West Suffolk Hospital Coordinator of this site? Confirm its status | Bury St Edmunds | United Kingdom | Recruiting |
| Cambridge University Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Cambridge | United Kingdom | Recruiting |
| East Kent Hospitals University NHS Foundation Trust Coordinator of this site? Confirm its status | Canterbury | United Kingdom | Recruiting |
| Cardiff and Wales University Local Health Board Coordinator of this site? Confirm its status | Cardiff | United Kingdom | Recruiting |
| North Cumbria Integrated Care NHS Foundation Trust Coordinator of this site? Confirm its status | Carlisle | United Kingdom | Recruiting |
| Epsom and St Helier University Hospitals NHS Trust Coordinator of this site? Confirm its status | Carshalton | United Kingdom | Recruiting |
| Gloucestershire Hospital NHS Foundation Trust Coordinator of this site? Confirm its status | Cheltenham | United Kingdom | Recruiting |
| Portsmouth Hospitals University NHS Trust Coordinator of this site? Confirm its status | Cosham | United Kingdom | Recruiting |
| University Hospitals Coventry & Warwickshire Coordinator of this site? Confirm its status | Coventry | United Kingdom | Recruiting |
| University Hospitals of Derby and Burton Coordinator of this site? Confirm its status | Derby | United Kingdom | Recruiting |
| Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Doncaster | United Kingdom | Recruiting |
| Dorset County Hospital NHS Foundation Trust Coordinator of this site? Confirm its status | Dorchester | United Kingdom | Recruiting |
| The Dudley Group Nhs Foundation Trust Coordinator of this site? Confirm its status | Dudley | United Kingdom | Recruiting |
| Royal Devon and Exeter NHS Foundation Trust Coordinator of this site? Confirm its status | Exeter | United Kingdom | Recruiting |
| NHS Greater Glasgow and Clyde Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Recruiting |
| James Paget University Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Great Yarmouth | United Kingdom | Recruiting |
| Hull University Teaching Hospital NHS Trust Coordinator of this site? Confirm its status | Hull | United Kingdom | Recruiting |
| Nhs Highland Coordinator of this site? Confirm its status | Inverness | United Kingdom | Recruiting |
| Ipswich Hospital (East Suffolk & North Essex Foundation Trust) Coordinator of this site? Confirm its status | Ipswich | United Kingdom | Recruiting |
| NHS Ayrshire and Arran Coordinator of this site? Confirm its status | Kilmarnock | United Kingdom | Recruiting |
| University Hospitals of Leicester NHS Trust Coordinator of this site? Confirm its status | Leicester | United Kingdom | Recruiting |
| University Hospital Aintree Coordinator of this site? Confirm its status | Liverpool | United Kingdom | Recruiting |
| Royal Liverpool University Hospitals Coordinator of this site? Confirm its status | Liverpool | United Kingdom | Recruiting |
| King's College Hospital NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Guy's and St Thomas' NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| St. George's University Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Manchester University NHS Foundation Trust Coordinator of this site? Confirm its status | Manchester | United Kingdom | Recruiting |
| South Tees Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Middlesbrough | United Kingdom | Recruiting |
| The Newcastle Upon Tyne Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Newcastle upon Tyne | United Kingdom | Recruiting |
| Nottingham University Hospitals NHS Trust Coordinator of this site? Confirm its status | Nottingham | United Kingdom | Recruiting |
| University Hospitals Plymouth NHS Trust Coordinator of this site? Confirm its status | Plymouth | United Kingdom | Recruiting |
| Royal Berkshire NHS Foundation Trust Coordinator of this site? Confirm its status | Reading | United Kingdom | Recruiting |
| Salford Royal NHS Foundation Trust Coordinator of this site? Confirm its status | Salford | United Kingdom | Recruiting |
| Sheffield Teaching Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Sheffield | United Kingdom | Recruiting |
| Shrewsbury and Telford Hospital NHS Trust Coordinator of this site? Confirm its status | Shrewsbury | United Kingdom | Recruiting |
| Mid and South Essex NHS Foundation Trust Coordinator of this site? Confirm its status | Southend-on-Sea | United Kingdom | Recruiting |
| East and North Hertfordshire NHS Trust Coordinator of this site? Confirm its status | Stevenage | United Kingdom | Recruiting |
| University Hospital of North Midlands NHS Trust Coordinator of this site? Confirm its status | Stoke-on-Trent | United Kingdom | Recruiting |
| South Tyneside and Sunderland NHS Foundation Trust Coordinator of this site? Confirm its status | Sunderland | United Kingdom | Recruiting |
| The Royal Wolverhampton NHS Trust Coordinator of this site? Confirm its status | Wolverhampton | United Kingdom | Recruiting |
| York and Scarborough Teaching Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | York | United Kingdom | Recruiting |
| Hadassah University Coordinator of this site? Confirm its status | Jerusalem | Israel | Recruiting |
| Shaare Zedek Medical Centre Coordinator of this site? Confirm its status | Jerusalem | Israel | Recruiting |
| Meir Hospital Coordinator of this site? Confirm its status | Kfar Saba | Israel | Recruiting |
| Sheba Hospital Coordinator of this site? Confirm its status | Ramat Gan | Israel | Recruiting |
| Tel-Aviv Sourasky Medical Center Coordinator of this site? Confirm its status | Tel Aviv | Israel | Recruiting |
| Auckland City Hospital Coordinator of this site? Confirm its status | Auckland | New Zealand | Completed |
| Christchurch Hospital Coordinator of this site? Confirm its status | Christchurch | New Zealand | Completed |
| Dunedin Hospital Coordinator of this site? Confirm its status | Dunedin | New Zealand | Completed |
| Waikato DHB Coordinator of this site? Confirm its status | Hamilton | New Zealand | Completed |
| Hawkes Bay Hospital Coordinator of this site? Confirm its status | Hastings | New Zealand | Completed |
| Middlemore Hospital Coordinator of this site? Confirm its status | Otahuhu | New Zealand | Completed |
| Waitematā Hospital Coordinator of this site? Confirm its status | Takapuna | New Zealand | Completed |
| Northland DHB Coordinator of this site? Confirm its status | Whangarei | New Zealand | Completed |
| Tan Tock Seng Hospital Pte. Ltd. Coordinator of this site? Confirm its status | Singapore | Singapore | Recruiting |
| Woodlands Health Coordinator of this site? Confirm its status | Singapore | Singapore | Recruiting |
| Khoo Teck Puat Hospital Coordinator of this site? Confirm its status | Singapore | Singapore | Recruiting |
| Ramathibodi Hospital Coordinator of this site? Confirm its status | Bangkok | Thailand | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.