NCT03587961RecruitingEarly phase 1
Personalized Theratyping Trial
Source: ClinicalTrials.gov · Last updated 2 Feb 2026
Brief summary (registry, in English)
The purpose of this study is to explore the use of off-label CFTR modulators that may affect CFTR function in patients with CFTR mutations that are not currently approved for these drugs.
- Status (registry)
- Recruiting
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 3 Jul 2018
- Start date
- 1 Aug 2019
- Primary completion date
- 1 Jan 2027
- Lead sponsor
- George Solomon
- Diseases
- Cystic fibrosis
- NCT number
- NCT03587961
What you commit to
- Study type: Interventional · Early phase 1
- Planned participants: 20
- From 1 Aug 2019 to the primary completion date, 1 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Exacerbation requiring antibiotic or steroids for \>28 days before trial entry
- Any meds that have significant drug-drug interactions or any other off label use of CFTR modulators
Other illness
- History of solid organ transplant
- Any condition which precludes the use of CFTR modulators: e.g. advanced cirrhosis, End-stage Renal Disease (ESRD)
- Any condition that precludes the patient from participation in the opinion of the investigator
Other
- Ongoing participation in a CFTR modulator study
- Active smoking in the past 6 months
Who the study is looking for
- Diagnosis of CF
- Age ≥6 y.o.
- CFTR mutation that may respond to approved correctors/potentiators in the opinion of the study investigators
- Informed Consent/Assent
- Stable CF pulmonary regimen
Age in the registry: 6 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Alabama at Birmingham Coordinator of this site? Confirm its status | Birmingham | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.