NCT03592329Completed
Vagus Nerve Stimulation and Stress Reduction Training for Migraine
Brain Mechanisms of Vagus Nerve Stimulation and Stress Reduction Training for Migraine
Source: ClinicalTrials.gov · Last updated 25 Feb 2026
Brief summary (registry, in English)
This study design has two components: 1) a cross-sectional assessment of brain activity and inflammation in migraine patients compared to healthy controls and 2) an assessment of 8 weeks of a combination therapy approach to treating migraine.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 193 (actual)
- First submitted
- 24 May 2018
- Start date
- Aug 2019
- Primary completion date
- Jan 2025
- Lead sponsor
- Massachusetts General Hospital
- Diseases
- Migraine
- NCT number
- NCT03592329
What you commit to
- Study type: Interventional
- Participants enrolled: 193
- From Aug 2019 to the primary completion date, Jan 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous experience with stress reduction training (such as mindfulness training, MBSR, MBCT, Relaxation Response) or more than 15 home mediation practice sessions in the past month, or more than 10 classes in yoga, Tai Chi, or Qi Gong in the past 3 months
Other illness
- Major illness, psychiatric condition, or neurological disease.
- Any condition that would prohibit MRI scanning
- Healthy Volunteers have the same eligibility constraints with the addition of current or past history of migraine.
Who the study is looking for
- Subjects must be between 18 and 65 years of age.
- Migraine Diagnosis and general health otherwise.
- Willingness to attend twice- weekly treatment session at Cambridge Health Alliance for 8 weeks.
- Able to give written consent and participate in group interventions in English.
- Healthy Volunteers between the ages of 18 and 65 can participate in this study.
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Anthinoula A. Martinos Center Coordinator of this site? Confirm its status | Charlestown | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.