NCT03596268Completed
Functional Imaging Reserve in NeuroHIV
Source: ClinicalTrials.gov · Last updated 29 Aug 2025
Brief summary (registry, in English)
The purpose of this research study is to look at the brain's efficiency and ability to make up for deficits in the front of the brain to see if people living with HIV (PLWH) are still able to perform well on various cognitive tasks even though there are other underlying processes at work, like inflammation, that affect the brain in a negative way. Results of this study may provide insight into the pathophysiology of disease and may reveal arenas for future possible interventions in PLWH who have impaired neuropsychological performance.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 284 (actual)
- First submitted
- 9 Jul 2018
- Start date
- 20 Nov 2018
- Primary completion date
- 30 Apr 2025
- Lead sponsor
- Washington University School of Medicine
- Diseases
- HIV
- NCT number
- NCT03596268
What you commit to
- Study type: Observational
- Participants enrolled: 284
- From 20 Nov 2018 to the primary completion date, 30 Apr 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- significant neurological disorders (e.g. stroke, head injury with loss of consciousness for more than 5 minutes, developmental learning disability)
- active uncontrolled Axis I psychiatric disorder according to the DSM 5
- current or history of substance use disorder (including, but not limited to amphetamines, cocaine, alcohol, opiates, and barbiturates)
- allergic to lidocaine or similar anesthetic
- history of any bleeding disorder
Other
- prescribed blood thinners
- contraindication to MRI scanning (e.g. claustrophobia, pacemaker, etc.)
- pregnant or breastfeeding
Who the study is looking for
- 20 to 80 years old
- documented HIV infection for at least 1 year or confirmed HIV - status
- PLWH must be on stable cART regimen for at least 12 months with undetectable plasma HIV RNA (less than 50 copies per mL)
- at least 9 years of education
- able to provide informed consent
- if female, a negative pregnancy test and not breast feeding
- able to undergo an MRI scan
Age in the registry: 20 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Washington University School of Medicine Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.