NCT03609437Active, not recruiting
Impaired Endothelial Integrity in Patients With Embolic Stroke of Undetermined Source (ESUS)
Impaired Endothelial Glycocalyx Integrity and Arterial Elastic Properties in Patients With Embolic Stroke of Undetermined Source (ESUS)
Source: ClinicalTrials.gov · Last updated 15 Jul 2025
Brief summary (registry, in English)
The investigators will measure endothelial glycocalyx, aortic elastic properties, oxidative stress, and their association with left ventricular (LV) and left atrial (LA) function in ESUS, cardioembolic, atherosclerotic, lacunar strokes and age- and sex-adjusted healthy individuals.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 215 (estimated)
- First submitted
- 15 Jul 2018
- Start date
- 1 Jan 2018
- Primary completion date
- 30 Oct 2025
- Lead sponsor
- University of Athens
- Diseases
- Stroke
- NCT number
- NCT03609437
What you commit to
- Study type: Observational
- Planned participants: 215
- From 1 Jan 2018 to the primary completion date, 30 Oct 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- the history of previous Ischemic stroke and/or Myocardial Infarction (MI),
Other illness
- presence of acute haemorrhagic stroke,
- the presence of stroke of other determined etiology,
- active malignancy
Lab values
- severe chronic kidney disease (eGFR\<30 ml/minute). These exclusion criteria are applied to both patients and control subjects.
Other
- hypercoagulable state,
Who the study is looking for
- The investigators plan to include participants with Acute Ischemic Stroke, based on the TOAST classification : 1) large artery atherosclerosis (atherothrombotic), 2) cardioembolic, 3) small artery occlusion (lacunar), 4) stroke of undetermined etiology (ESUS). According to the TOAST classification, diagnoses are based on clinical presentation and on data collected by exams such as brain imaging (CT/MRI), cardiac imaging (echocardiography) and laboratory tests for the prothrombotic state. The diagnosis of Embolic Stroke of Undetermined Source (ESUS) was established based on the criteria defined by the Cryptogenic Stroke/ESUS International Working Group.
Age in the registry: 18 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Konstantinos Katogiannis Coordinator of this site? Confirm its status | Athens | Greece | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.