NCT03612531Active, not recruiting
Manual Therapy in Treating Fibrosis-Related Late Effect Dysphagia in Head and Neck Cancer Survivors
Manual Therapy for Fibrosis-Related Late Effect Dysphagia in Head and Neck Cancer Survivors: The Pilot MANTLE Trial
Source: ClinicalTrials.gov · Last updated 13 Oct 2026
Brief summary (registry, in English)
This trial studies how well manual therapy works in treating fibrosis-related late effect dysphagia in head and neck cancer survivors. Manual therapy is the use of massage and stretching exercises to increase blood flow and muscle movement in the neck, throat, jaw, and mouth, which may help to improve swallowing ability and range of motion in participants who have had treatment for head and neck cancer.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 26 (actual)
- First submitted
- 26 Jul 2018
- Start date
- 6 Aug 2018
- Primary completion date
- 15 Jul 2022
- Lead sponsor
- M.D. Anderson Cancer Center
- Diseases
- Head and neck cancer
- NCT number
- NCT03612531
What you commit to
- Study type: Interventional
- Participants enrolled: 26
- From 6 Aug 2018 to the primary completion date, 15 Jul 2022
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Active recurrent or second primary head and neck, central nervous system, or thoracic cancer at time of enrollment
- Active osteoradionecrosis or other non-healing wounds (e.g., fistula, ulcer, soft tissue necrosis) in manual therapy (MT) regions of interest at time of enrollment
- History of subtotal or total glossectomy or total laryngectomy
- Functionally limiting cardiac, pulmonary, or neuromuscular disease
Other
- Current tracheostomy
Who the study is looking for
- Late Dynamic Imaging Grade of Swallowing Toxicity (DIGEST) grade \>= 2 dysphagia on Modified Barium Swallow (MBS) \>= 2 years after curative-intent radiotherapy for head and neck cancer
- Grade \>= 2 Common Terminology Criteria for Adverse Events (CTCAE) fibrosis
- Willing and able to return for 10 sessions over 6 weeks of therapy
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| M D Anderson Cancer Center Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.