NCT03619863Completed
ATHN 7: Hemophilia Natural History Study
A Natural History Cohort Study of the Safety, Effectiveness, and Practice of Treatment for People With Hemophilia
Source: ClinicalTrials.gov · Last updated 12 Feb 2025
Brief summary (registry, in English)
This is a real-world study of the safety of the treatments used for people with hemophilia. The study will follow people with hemophilia A or B from across the country for about 4 years as they receive treatment. The hemophilia treatment center (HTC) physician and participant will decide on the FDA-approved treatment to be used which may include non-factor products, bypassing agents, or clotting factor replacement products. The goal of this research is to study the use of hemophilia treatment products and their outcomes.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 395 (actual)
- First submitted
- 25 Jul 2018
- Start date
- 24 Oct 2018
- Primary completion date
- 31 May 2023
- Lead sponsor
- American Thrombosis and Hemostasis Network
- Diseases
- Haemophilia
- NCT number
- NCT03619863
What you commit to
- Study type: Observational
- Participants enrolled: 395
- From 24 Oct 2018 to the primary completion date, 31 May 2023
- 29 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Presence of concurrent hemophilia and a second hemostatic defect (low Von Willebrand Factor (VWF) without Von Willebrand disease (VWD) diagnosis is not excluded); and
Other illness
- Presence of any known bleeding disorder other than congenital hemophilia A or B;
Other
- Unable or unwilling to comply with the study protocol.
Who the study is looking for
- Congenital hemophilia A or B of any severity with or without inhibitors receiving a current therapy, a non-factor product, or for whom use of a non-factor product is a possibility;
- Able to give informed consent (by patient or parent/authorized guardian); and
- Co-enrollment in the ATHNdataset.
Sex: All · Does not accept healthy volunteers
Sites (29)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Comprehensive Bleeding Disorders Center at Emory University and Children's Healthcare of Atlanta Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| Hemophilia and Thrombosis Center/ University of Colorado Anschutz Medical Campus Coordinator of this site? Confirm its status | Aurora | United States | Unknown status |
| Massachusetts General Hospital Comprehensive Hemophilia and Thrombosis Treatment Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Rush University Medical Center Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| The Center for Cancer and Blood Disorders, Children's Medical Center of Dallas Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Michigan State University Center for Bleeding and Clotting Disorders Coordinator of this site? Confirm its status | East Lansing | United States | Unknown status |
| University of Florida Hemophilia Treatment Center Coordinator of this site? Confirm its status | Gainesville | United States | Unknown status |
| Gulf States Hemophilia and Thrombosis Center Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Indiana Hemophilia and Thrombosis Center (IHTC) Coordinator of this site? Confirm its status | Indianapolis | United States | Unknown status |
| Children's Mercy Hospital, Kansas City Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| Hemostasis and Thrombosis Center of Nevada Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Orthopedic Institute for Children Hemophilia Program Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Orthopaedic Institute for Children HTC Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| St. Jude Children's Research Hospital Coordinator of this site? Confirm its status | Memphis | United States | Unknown status |
| Comprehensive Center for Bleeding Disorders Coordinator of this site? Confirm its status | Milwaukee | United States | Unknown status |
| Newark Beth Israel Medical Center Coordinator of this site? Confirm its status | Newark | United States | Unknown status |
| Louisiana Center for Bleeding and Clotting Disorders Coordinator of this site? Confirm its status | New Orleans | United States | Unknown status |
| Louisiana Center for Bleeding and Clotting Disorders, Tulane University Coordinator of this site? Confirm its status | New Orleans | United States | Unknown status |
| Weill Cornell Medicine Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Penn Comprehensive Hemophilia and Thrombophilia Program/Hospital of the University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Children's Hospital of Philadelphia (CHOP) Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Arizona Hemophilia and Thrombosis Center at Phoenix Children's Hospital Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| The Hemophilia Center at Oregon Health & Science University Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Hemostasis and Thrombosis Center of Nevada Coordinator of this site? Confirm its status | Reno | United States | Unknown status |
| Rady Children's Hospital - San Diego Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
| Maine Hemophilia and Thrombosis Center Coordinator of this site? Confirm its status | Scarborough | United States | Unknown status |
| The John Bouhasin Center for Children with Bleeding Disorders Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Northwest Ohio Hemophilia Treatment Center at the Toledo Hospital Coordinator of this site? Confirm its status | Toledo | United States | Unknown status |
| Wake Forest University Health Science Coordinator of this site? Confirm its status | Winston-Salem | United States | Unknown status |
Related publications
- Safety and Effectiveness of Emicizumab in People With Haemophilia A Enrolled in the ATHN 7 Haemophilia Natural History Study.Haemophilia · 2026 · PMID 41220279
This page is information, not medical advice. Discuss any trial with your doctor.