NCT03654573CompletedPhase 1
The MOCA I Study - Microvascular Obstruction with CoFI™ System Assessment
Source: ClinicalTrials.gov · Last updated 19 Mar 2025
Brief summary (registry, in English)
First-in-Human study to assess the CoFI™ device related safety and the feasibility of the diagnostic and the therapeutic sequence as well as the correlation between the dynamic microvascular resistance (dMVR) and microvascular obstruction (MVO) as measured by MRI in patients presenting with acute ST-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI).
- Status (registry)
- Completed
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 73 (actual)
- First submitted
- 16 Aug 2018
- Start date
- 4 Jun 2019
- Primary completion date
- 18 Dec 2024
- Lead sponsor
- CorFlow Therapeutics AG
- Diseases
- Coronary artery disease
- NCT number
- NCT03654573
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 73
- From 4 Jun 2019 to the primary completion date, 18 Dec 2024
- 8 sites in 3 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- Major Inclusion Criteria:
- Patients 18 years of age or older presenting with ST-elevation myocardial infarction in the left anterior descending artery (LAD) undergoing primary percutaneous coronary intervention.
- Competent mental condition to provide signed and dated ethics committee approved study consent prior to study related procedures
- Eligible for prasugrel, ticagrelor, cangrelor, tirofiban, UFH and GP IIb/IIIa inhibitors
- Referred for primary PCI within 5 hours of symptom onset with evidence of continuing ischemia and symptom to balloon time not exceeding 6 hours
- Major Exclusion Criteria:
- Unconsciousness
- Previous bypass graft surgery
- Contraindication to CMRI
- Recent or current major bleeding within 30 days prior to intervention
- Recent major surgery within 30 days prior to intervention
- End-stage heart failure with inotrope support and/or consideration for LVAD or heart transplant
- Transient ischemic attack or stroke within 30 days prior to intervention
- Pregnant or females of childbearing potential
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (8)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Inselspital Bern Coordinator of this site? Confirm its status | Bern | Switzerland | Unknown status |
| HUG Geneva Coordinator of this site? Confirm its status | Geneva | Switzerland | Unknown status |
| CHUV Lausanne Coordinator of this site? Confirm its status | Lausanne | Switzerland | Unknown status |
| Cardiocentro Ticino Coordinator of this site? Confirm its status | Lugano | Switzerland | Unknown status |
| Universitätsspital Zürich Coordinator of this site? Confirm its status | Zurich | Switzerland | Unknown status |
| Leeds Teaching Hospitals NHS Trust Coordinator of this site? Confirm its status | Leeds | United Kingdom | Unknown status |
| The Hospital of Lithuanian University of Health Sciences (LSMU) Kauno klinikos Coordinator of this site? Confirm its status | Kaunas | Lithuania | Unknown status |
| Vilnius University Hospital Santariškių Klinikos Coordinator of this site? Confirm its status | Vilnius | Lithuania | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.