NCT03659981Active, not recruiting
Grey Matter Damage at the Earliest Phase of Multiple Sclerosis : a Longitudinal 7T MRI Study
Grey Matter Damage at the Earliest Phase of Multiple Sclerosis : a Longitudinal 7T Magnetic Resonance Imaging Study
Source: ClinicalTrials.gov · Last updated 6 Aug 2024
Brief summary (registry, in English)
The present study is an opportunity to assess grey matter damage at the earliest phase of Multiple Sclerosis (MS) allowing to a better understanding of its origins and its impact and disease severity. This study is a preliminary longitudinal study to precisely depict the kinetic of grey matter damage and the links with disease aggravation. Thirty MS patients without time and spatial dissemination criteria (only one symptomatic MRI lesion detected) but with oligoclonal bands detected on cerebro spinal fluid analysis will be included for a monocentric transversal MRI study at 7T to assess grey matter injury. Clinical and neuropsychological assessments will be performed in the population the same day of a multi-parametric MRI. A longitudinal clinical and MRI follow up will be performed during 2 years.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 32 (actual)
- First submitted
- 4 Sept 2018
- Start date
- 20 Dec 2018
- Primary completion date
- 19 May 2022
- Lead sponsor
- Assistance Publique Hopitaux De Marseille
- Diseases
- Multiple sclerosis
- NCT number
- NCT03659981
What you commit to
- Study type: Interventional
- Participants enrolled: 32
- From 20 Dec 2018 to the primary completion date, 19 May 2022
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous history of neurological or psychiatric disease
- Previous administration of immunosuppressive drugs
Other
- Possible alternative diagnoses
- Pregnancy
- Patient unable to give his consent for the study or patient under tutorship
Who the study is looking for
- First presumed inflammatory demyelinating event in the central nervous system involving either the optic nerve, the spinal cord, a brain hemisphere, or the brainstem without spatial and time dissemination criteria
- Oligoclonal bands on CSF analysis
- Age between 18 and 45
- No previous history of neurological symptoms suggestive of demyelination
- No steroids in the month before MRI
- First MRI within six months after the first clinical episode
Age in the registry: 18 years to 50 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Assistance Publique Des Hopitaux de Marseille Coordinator of this site? Confirm its status | Marseille | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.