NCT03669822Completed
Multi-center Acute Severe Ulcerative Colitis Cohort Study (MASCC)
Source: ClinicalTrials.gov · Last updated 24 Jan 2025
Brief summary (registry, in English)
Ulcerative colitis (UC) is a chronic, progressive immunologically mediated disease affecting nearly 1 million Americans. Up to one third of patients with UC will require hospitalization for severe disease (termed 'acute severe colitis (ASUC)'), often within the first year after diagnosis. Investigators will develop a large multi-center cohort of patients with ASUC with homogeneously collected detailed longitudinal clinical and laboratory data.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 97 (actual)
- First submitted
- 29 May 2018
- Start date
- Nov 2018
- Primary completion date
- Dec 2024
- Lead sponsor
- Johns Hopkins University
- Diseases
- Ulcerative colitis
- NCT number
- NCT03669822
What you commit to
- Study type: Observational
- Participants enrolled: 97
- From Nov 2018 to the primary completion date, Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior colitis related surgery including J-pouch or stoma
Other illness
- Patients with quiescent disease
Other
- Inability to provide informed consent
- Non-IBD related hospital admission
- Women who are pregnant (from the specimen substudy only)
- Non - English speaking
Who the study is looking for
- Patients 18-80 years
- UC or IBD-unspecified (IBDU) diagnosed according to standard criteria
- Active disease defined as Simple Clinical Colitis Activity Index \> 2 (day/night bowel frequency, urgency with defecation, blood in stool, general well-being, and extracolonic features)
- Admitted to the hospital
- Initiating intravenous corticosteroid therapy or medical rescue therapy
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Joanna Melia Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.