NCT03670615Completed
Using Exercise and Electrical Brain Stimulation to Improve Memory in Dementia
Exercise Augmenting Cognition tDCS (EXACT): A Pilot Study of a Combined Exercise and Transcranial Direct Current Stimulation Intervention for Cognition
Source: ClinicalTrials.gov · Last updated 30 Mar 2026
Brief summary (registry, in English)
Mild cognitive impairment and Alzheimer's disease are conditions that involve memory difficulties. Transcranial direct current stimulation is a type of brain stimulation. It may help improve these memory difficulties. However, it works better on active brain areas. This study looks at if combining exercise and applying current to important parts of the brain can help improve memory in people with Mild Cognitive Impairment or Alzheimer's disease.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 22 Aug 2018
- Start date
- 28 Nov 2018
- Primary completion date
- 1 Aug 2025
- Lead sponsor
- Sunnybrook Health Sciences Centre
- Diseases
- Alzheimer disease
- NCT number
- NCT03670615
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 28 Nov 2018 to the primary completion date, 1 Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Change in cognitive enhancing medications (ChEIs and/or memantine) less than 3 months prior to study screen
- Change in anticonvulsants or psychotropic medications less than 1 month prior to study screen
- Currently taking benzodiazepines
- Presence of metal implants that would preclude safe use of tDCS (e.g. pace-maker)
Other illness
- Significant neurological condition (e.g. epilepsy, Parkinson's disease, multiple sclerosis)
- Current psychiatric disorders (e.g. schizophrenia, bipolar disorder, depression, psychosis) or current substance use disorder
Other
- Medical contraindications to increasing activity level according to the Canadian Society of Exercise Physiology Questionnaire
Who the study is looking for
- Males or females ≥50 years of age
- DSM-5 criteria for major or mild neurocognitive disorder due to AD or mixed AD/vascular disease
- Mild severity of impairment (standardized Mini-Mental State Examination (MMSE) score ≥19)
- Read and communicate in English
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Sunnybrook Health Sciences Centre Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.