NCT03674307Active, not recruiting
Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates
Canadian-Australasian Randomised Trial of Screening Kidney Transplant Candidates for Coronary Artery Disease
Source: ClinicalTrials.gov · Last updated 6 Jul 2026
Brief summary (registry, in English)
The Canadian Australasian Randomized Trial of Screening Kidney Transplant Candidates for Coronary Artery Disease (CARSK) will test the hypothesis that eliminating the regular use of non-invasive screening tests for CAD AFTER waitlist activation is not inferior to regular (i.e., annual) screening for CAD during wait-listing for the prevention of Major Adverse Cardiac Events. Secondary analyses will assess the impact of screening on the rate of transplantation, and the relative cost-effectiveness of screening.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 3306 (actual)
- First submitted
- 5 Sept 2018
- Start date
- 1 Dec 2018
- Primary completion date
- 26 Jan 2028
- Lead sponsor
- University of British Columbia
- NCT number
- NCT03674307
What you commit to
- Study type: Interventional
- Participants enrolled: 3306
- From 1 Dec 2018 to the primary completion date, 26 Jan 2028
- 22 sites in 4 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- patients who "on-hold" for transplantation due to a medical problem;
- multi-organ transplant candidates (e.g. kidney-pancreas transplant candidates);
- patients with planned living donor transplant;
Other illness
- patients with signs or symptoms suggestive of uncontrolled cardiac disease such as unstable coronary syndromes, decompensated heart failure, uncontrolled arrhythmia, and severe valvular heart disease;
Other
- patients with other solid organ transplants;
- patients unable to give consent.
Who the study is looking for
- adults aged 18 years of age or older
- Dialysis-dependent kidney failure and currently being assessed for OR active on the kidney transplant waiting list
- expected to require further screening for CAD prior to transplantation (by current standard of care);
- able to give consent;
- anticipated to undergo transplantation more than 12 months from date of enrolment
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (22)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Alberta Coordinator of this site? Confirm its status | Edmonton | Canada | Unknown status |
| Dalhousie University Coordinator of this site? Confirm its status | Halifax | Canada | Unknown status |
| St. Joseph's Healthcare Coordinator of this site? Confirm its status | Hamilton | Canada | Unknown status |
| Kingston Health Science Centre Coordinator of this site? Confirm its status | Kingston | Canada | Unknown status |
| CHU de Quebec-Universite Laval's L'Hotel-Dieu de Quebec Coordinator of this site? Confirm its status | Laval | Canada | Unknown status |
| London Health Science Centre Coordinator of this site? Confirm its status | London | Canada | Unknown status |
| Universite de Montreal - Hopital Maisonneuve-Rosemont Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| University of Montreal, Maisonneuve-Rosemont Hospital Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| McGill University Health Centre Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| The Ottawa Hospital Research Institute Coordinator of this site? Confirm its status | Ottawa | Canada | Unknown status |
| St. Paul's Hospital, University of Saskatchewan Coordinator of this site? Confirm its status | Saskatoon | Canada | Unknown status |
| St. Michael's Hospital Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| University Health Network Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| University of British Columbia Coordinator of this site? Confirm its status | Vancouver | Canada | Unknown status |
| Charité - Universitätsmedizin Coordinator of this site? Confirm its status | Berlin | Germany | Unknown status |
| Sussex Brighton R&D Coordinator of this site? Confirm its status | Brighton | United Kingdom | Unknown status |
| King's College Hospital NHS Foundation Trust Coordinator of this site? Confirm its status | Brixton | United Kingdom | Unknown status |
| Epsom and St Helier University Hospitals NHS Trust Coordinator of this site? Confirm its status | Carshalton | United Kingdom | Unknown status |
| St George's University Hospital NHS Trust Foundation Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Barts Health NHS Trust Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| University of Arizona Coordinator of this site? Confirm its status | Tucson | United States | Unknown status |
| The George Washington University Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.