NCT03675412Completed
Caffeine Consumption in Glaucoma Patients and Healthy Subjects
Acute Changes in Optic Nerve Head (ONH) and Macular Blood Flow After Caffeine Consumption in Glaucoma Patients and Healthy Subjects: A Quantitative Optic Coherence Tomography Angiography (OCTA) Study
Source: ClinicalTrials.gov · Last updated 13 Oct 2026
Brief summary (registry, in English)
Caffeine is the most widely consumed drinking nutrient in the world. Caffeine effects various organs and the vascular system. It decreases ocular blood flow due to vasoconstriction.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 18 (actual)
- First submitted
- 5 Sept 2018
- Start date
- Dec 2018
- Primary completion date
- Feb 2024
- Lead sponsor
- Wills Eye
- Diseases
- Glaucoma
- NCT number
- NCT03675412
What you commit to
- Study type: Interventional
- Participants enrolled: 18
- From Dec 2018 to the primary completion date, Feb 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- current macular edema, prior laser to retina, inflammatory retinopathy or choroidopathy
Other illness
- Diseases, ophthalmic or systemic, that are likely to affect OCTA results
- rheumatologic diseases or Raynaud's phenomena
- mental illness or alcohol addiction
- pre-existing bladder symptoms, cardiac disease or sleep disorder
Other
- greater than moderate cataract
- nystagmus
- inability to look at target
- macular degeneration other than mild drusen or pigmentary changes
- diabetic retinopathy
- neovascular glaucoma or non-glaucoma optic neuropathies
- keratoconus, corneal ectasia, central corneal scarring
- pregnant and lactating women
- refractive spherical diopter greater than 5 or cylinder greater than 3
- possible tolerance to caffeine (drinking more than 1 cup coffee per day).
Who the study is looking for
- age 18 to 90 years
- diagnosis of primary open angle glaucoma (Mild, Moderate and Advanced)
- healthy subjects with no eye disease
Age in the registry: 18 years to 90 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Wills Eye Glaucoma Service Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.