NCT03678831Completed
Characteristics of Marrow Fatty Cells in the Ageing of Bone and Joints, Osteoarthritis and Osteoporosis
Characterization of Bone Marrow Adipocytes in Osteoarthritic and Post-menopausal Patients: a Comparative Study With Adipocytes From Subcutaneous Adipose Tissue
Source: ClinicalTrials.gov · Last updated 5 Dec 2025
Brief summary (registry, in English)
Obesity and other associated complications promote the development and the progression of osteoarthritis. The subcutaneous and abdominal fat release several factors that alter bone and the cartilage. The role of the marrow fat in close connection with bone has not been defined yet, whereas cellular and animal models indicate that this fat depot modifies bone and cartilage. The aim of the study is to define if the marrow fat produces more joint-altering factors by comparison with subcutaneous fat. This fat depot can be characterized from removed pieces during the prosthetic surgery of the knee. Measuring before surgery the body weight, waist and hip circumferences, blood pressure, glucose, insulin and lipids in blood will also allow to determine if obesity and/or type 2 diabetes make this fat more dangerous for the joint. Such research will allow the elaboration of new therapeutic strategies in osteoarthritis.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 45 (actual)
- First submitted
- 18 Sept 2018
- Start date
- 30 Jun 2020
- Primary completion date
- 11 Mar 2024
- Lead sponsor
- University Hospital, Lille
- Diseases
- Obesity, Type 2 diabetes, Osteoporosis
- NCT number
- NCT03678831
What you commit to
- Study type: Observational
- Participants enrolled: 45
- From 30 Jun 2020 to the primary completion date, 11 Mar 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- with previous surgery at the surgery site
- --with a current participation to another study
Other illness
- with active infection
- with evolving cancer
- with type 1 diabetes
Lab values
- with haematopoietic pathologies such as haemoglobin pathologies
- with anti-osteoporotic treatments (bisphosphonates, strontium ranelate, teriparatide, denosumab) except calcium and vitamin D supplementation or hormone replacement.
Other
- with refusal to participate to the study
- more than 85-year-old
- with bone pathologies other than osteoarthritis or osteoporosis
- with thyroid pathologies
- with replacement of prosthesis
- with guardianship
- with deprived liberty
Who the study is looking for
- Post-menopausal woman
- with a symptomatic knee osteoarthritis requiring prosthesis
- able to handle general anaesthesia
- having given her consent
- able to understand the constraints associated with the study
- with health insurance
- able to understand the French language
Age in the registry: 18 years to 85 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hopital Roger Salengro, CHU Lille Coordinator of this site? Confirm its status | Lille | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.