NCT03682991Active, not recruiting
Reversal of Atrial Substrate to Prevent Atrial
Reversal of Atrial Substrate to Prevent Atrial Fibrillation
Source: ClinicalTrials.gov · Last updated 17 Feb 2026
Brief summary (registry, in English)
A multi-center, randomized trial to examine the effect of aggressive risk factor control and arrhythmia trigger-based intervention on recurrence of atrial fibrillation.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 509 (actual)
- First submitted
- 27 Aug 2018
- Start date
- 1 Jul 2019
- Primary completion date
- 15 Sept 2027
- Lead sponsor
- Nova Scotia Health Authority
- Diseases
- Atrial fibrillation
- NCT number
- NCT03682991
What you commit to
- Study type: Interventional
- Participants enrolled: 509
- From 1 Jul 2019 to the primary completion date, 15 Sept 2027
- 17 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior catheter ablation for AF
Other illness
- New York Heart Association (NYHA) Class IV (Severe) heart failure,
- Participation in a cardiac rehabilitation program within the last year,
- Other noncardiovascular medical condition making 1 year survival unlikely,
Age
- Permanent AF (AF lasting \> 3 years)
- Less than 18 years of age.
Other
- Currently performing exercise training \>150 minutes/week of moderate to vigorous physical activity,
- Unable to exercise,
- Unable to give informed consent,
Who the study is looking for
- BMI ≥ 27,
- BP ≥140/90 mmHg or history of hypertension,
- Prior stroke/transient ischemic attack,
- Diabetes,
- Heart failure (prior heart failure admission or left ventricle ejection fraction (LVEF) \<40%),
- Age ≥ 65 years
- Current smoker
- Excessive Alcohol use
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (17)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Foothills Hospital Coordinator of this site? Confirm its status | Calgary | Canada | Unknown status |
| Mazankowski Alberta Heart Institute Coordinator of this site? Confirm its status | Edmonton | Canada | Unknown status |
| QE II Health Sciences Centre Coordinator of this site? Confirm its status | Halifax | Canada | Unknown status |
| Hamilton Health Sciences Center Coordinator of this site? Confirm its status | Hamilton | Canada | Unknown status |
| Kelowna General Health Coordinator of this site? Confirm its status | Kelowna | Canada | Unknown status |
| St. Mary's General Hospital Coordinator of this site? Confirm its status | Kitchener | Canada | Unknown status |
| Laval Hospital Coordinator of this site? Confirm its status | Laval | Canada | Unknown status |
| London Health Sciences Center Coordinator of this site? Confirm its status | London | Canada | Unknown status |
| Sacre Coeur Hospital Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Montreal Heart Institute Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| McGill University Health Centre Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Ottawa Heart Institute Coordinator of this site? Confirm its status | Ottawa | Canada | Unknown status |
| Regina General Hospital Coordinator of this site? Confirm its status | Regina | Canada | Unknown status |
| Saint John Regional Hospital Coordinator of this site? Confirm its status | Saint John | Canada | Unknown status |
| St. Michael's Hospital Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Sunnybrook Health Sciences Centre Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| St. Paul's Hospital Coordinator of this site? Confirm its status | Vancouver | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.