NCT03688503Completed
Magnesium Supplementation and Blood Pressure Reduction
Trial of Magnesium Supplementation and Blood Pressure Reduction Among Adults With Untreated High Blood Pressure
Source: ClinicalTrials.gov · Last updated 1 Oct 2025
Brief summary (registry, in English)
This double-blind, placebo-controlled randomized clinical trial will test whether a magnesium glycinate supplement (480 mg/day) taken for 12 weeks lowers blood pressure.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 59 (actual)
- First submitted
- 25 Sept 2018
- Start date
- 15 Feb 2019
- Primary completion date
- 9 Jan 2020
- Lead sponsor
- Brigham and Women's Hospital
- Diseases
- High blood pressure
- NCT number
- NCT03688503
What you commit to
- Study type: Interventional
- Participants enrolled: 59
- From 15 Feb 2019 to the primary completion date, 9 Jan 2020
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of antihypertensive use
- History of cardiovascular disease (myocardial infarction, stroke, revascularization \[coronary artery bypass graft or percutaneous transluminal coronary angioplasty\], or angina pectoris)
- History of invasive cancer diagnosed within the last 5 years (non-melanoma skin cancer permitted)
- History of type 1 or 2 diabetes
- History of renal disease
- History of kidney failure
- History of dialysis
- History of pancreatitis
- History of inflammatory bowel disease
- History of hypermagnesemia
Other
- Women who are pregnant, nursing, or intend to become pregnant during the treatment period
- Plan to relocate out of Boston area within the next year
- Unwillingness and/or inability to swallow 4 pills per day
- Inability to provide written informed consent
- Excessive antacid or laxative use within the past 3 months
Who the study is looking for
- Self-report of systolic blood pressure 120-139 mmHg or diastolic blood pressure 80-89 mmHg at prescreening
- Measured seated systolic blood pressure 120-149 mmHg or measured seated diastolic blood pressure 80-94 mmHg at screening visit
- Body mass index less than 40 kg/m2
- Total Mg intake from supplements of no more than 100 mg/day
- Willing to maintain current diet and supplement use patterns during the intervention period
Age in the registry: 30 years to 74 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Brigham and Women's Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.