NCT03698149Recruiting
ECoG BMI for Motor and Speech Control
A High-Performance ECoG-based Neural Interface for Communication and Neuroprosthetic Control
Source: ClinicalTrials.gov · Last updated 5 May 2026
Brief summary (registry, in English)
Test the feasibility of using electrocorticography (ECoG) signals to control complex devices for motor and speech control in adults severely affected by neurological disorders.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 3 (estimated)
- First submitted
- 21 Aug 2018
- Start date
- 9 Nov 2018
- Primary completion date
- 15 Aug 2030
- Lead sponsor
- Karunesh Ganguly
- Diseases
- Stroke, Multiple sclerosis
- NCT number
- NCT03698149
What you commit to
- Study type: Interventional
- Planned participants: 3
- From 9 Nov 2018 to the primary completion date, 15 Aug 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any prior intracranial surgery
Other illness
- Dementia, based on history, physical exam, and MMSE
- Active depression (BDI \> 20) or other psychiatric illness (active general anxiety disorder, schizophrenia, bipolar disorder, obsessive-compulsive disorder (OCD), or personality disorders (e.g. multiple personality disorder, borderline personality disorder, etc.)
- History of suicide attempt or suicidal ideation
- History of substance abuse
- Co-morbidities including ongoing anticoagulation, uncontrolled hypertension, cancer, or major organ system failure
- History of seizures
- Has an active infection
- Requires diathermy, electroconvulsive therapy (ECT), or transcranial magnetic stimulation (TMS) to treat a chronic condition
- Has an implanted electronic device such as a neurostimulator, cardiac pacemaker/defibrillator or medication pump, or presence of any head or neck metallic foreign bodies
- Allergies or known hypersensitivity to materials in the Blackrock NeuroPort Array (i.e. silicone, titanium) or the PMT Subdural Cortical Electrode (silicone, platinum iridium, nichrome)
Other
- Pregnancy or breastfeeding
- Inability to understand and/or read English
- Inability to give consent
- Inability to comply with study follow-up visits
- Immunocompromised
- Has a CSF drainage system or an active CSF leak
Who the study is looking for
- Age \> 21
- Limited ability to use upper limbs, based on neurological examination, due to stroke, amyotrophic lateral sclerosis (ALS), multiple sclerosis, cervical spinal cord injury, brainstem stroke, muscular dystrophy, myopathy or severe neuropathy.
- Disability, defined by a 4 or greater score on the Modified Rankin Scale, must be severe enough to cause loss of independence and inability to perform activities of daily living.
- If stroke or spinal cord injury, at least 1 year has passed since onset of symptoms
- Must live within a two-hour drive of UCSF
Age in the registry: 21 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of California San Francisco Coordinator of this site? Confirm its status | San Francisco | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.