Light Treatment Effectiveness (LITE) Study

Prior treatment

• Patients with known history of lack of efficacy to phototherapy or treated with phototherapy 14 days prior to baseline visit
• Patients deemed unsafe to be treated with phototherapy:
  • History of photosensitivity or autoimmune disease such as lupus or dermatomyositis which can be aggravated by ultraviolet radiation
  • History of arsenic intake
  • Unable to tolerate standing for required duration of treatment due to age or physical function
  • History of melanoma or multiple non-melanoma skin cancers that in the opinion of the principal investigator contraindicates treatment with phototherapy

Other illness

• Patients judged unable to follow home phototherapy protocol due to failure to demonstrate understanding of the following:
  • How to operate the phototherapy device
  • How to follow the dosing protocol
  • Requirement to wear protective eyewear and genital protection equipment

Other

• Patients who are judged unable or unwilling to comply with either in office or in home phototherapy due to time, work, school, or other financial constraints
• Psoriasis predominantly located on scalp, body folds, genitals, palms and/or soles or with a physician global assessment average of ≤ 1.0
• Clinical site deems the participant is ineligible for reason other than eligibility or screening criteria.

• Willing and able to provide informed consent (age 18+) or parental permission and assent (ages 12-17)
• Age 12 or older
• Plaque or guttate psoriasis predominantly located on trunk and/or extremities, with a physician global assessment average of \>1.0, and considered a candidate for phototherapy
• Patient is deemed willing and able to comply with either in-office or in-home phototherapy:
  • In office: Able to travel about 3 times per week for 12 weeks from home, work and/or school during business hours of local site
  • In home: Has space to accommodate home phototherapy unit and patient (or if 12-17, parent), willing and able to follow home phototherapy instructions
• New or established patient in the practice