NCT03727360Completed
Exercise for Brain Health in the Fight Against Alzheimer's Disease
Source: ClinicalTrials.gov · Last updated 1 May 2026
Brief summary (registry, in English)
The investigators aim to compare the effects of a 6-month moderate intensity exercise training (ET) intervention to a low intensity flexibility exercise control condition (FC) on brain function, cognition, and physical function in cognitively healthy and physically inactive older adults (ages 60-80). Apolipoprotein E epsilon4 (APOE-ε4) allele carriers are known to be at substantially greater risk for cognitive decline and Alzheimer's disease (AD). Cognitively intact APOE-ε4 allele carriers, and non-carriers, will be randomly assigned to 6-months of either supervised moderate intensity aerobic exercise training (ET) or supervised flexibility exercise control (FC). The ET and FC each contain a group based exercise component and are run in local retirement communities near College Park, MD, or on the University of Maryland College Park campus. The primary aims of the study are to compare pre-intervention to post-intervention changes in episodic memory performance and MRI biomarkers.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 124 (actual)
- First submitted
- 26 Oct 2018
- Start date
- 8 Oct 2018
- Primary completion date
- 30 Apr 2024
- Lead sponsor
- University of Maryland, College Park
- Diseases
- Alzheimer disease
- NCT number
- NCT03727360
What you commit to
- Study type: Interventional
- Participants enrolled: 124
- From 8 Oct 2018 to the primary completion date, 30 Apr 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current use of psychoactive medications, except selective serotonin/norepinephrine reuptake inhibitor antidepressants
- Use of acetylcholinesterase inhibitors (e.g., Aricept)
Other illness
- Neurological illnesses/conditions such as cerebral palsy, epi¬lepsy, brain tumor, chronic meningitis, multiple scle¬rosis, pernicious anemia, normal-pressure hydrocephalus, HIV infection, Parkinson's disease, and Huntington's disease
- Untreated hypertension, glaucoma, and chronic obstructive pul¬monary disease
- Unstable or severe cardiovascular disease or asthmatic condition
- History of transient ischemic attack, cerebral ischemia, or clinically diagnosed stroke
- Diagnosis of mild cognitive impairment or dementia, or objective evidence of cognitive impairment
Other
- Untreated severe major depression
- Substance abuse or dependence
Who the study is looking for
- 60 to 80 years old
- Fluent in English
- Willingness to make the time commitment to participate in the project, including randomization to treatments
- Physically inactive (physical activity not more than 2 days per week for the past 6 months)
- Physician consent to undergo an exercise stress test and engage in moderate intensity exercise
- Determined to be safe for MRI
Age in the registry: 60 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Maryland, Department of Kinesiology Coordinator of this site? Confirm its status | College Park | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.