NCT03729518Completed
TORS De-Intensification Protocol Version 2.0: Dose and Volume Reduction in the Neck
A Phase II Study of Volume and Dose De-Intensification Following Transoral Robotic Surgery (TORS) and Neck Dissection for p16+ Oropharyngeal Squamous Cell Carcinoma
Source: ClinicalTrials.gov · Last updated 22 Jul 2026
Brief summary (registry, in English)
This is a single-arm Phase II study of adjuvant radiation for locally advanced p16+ oropharyngeal squamous cell carcinoma. The main purpose of this research is to determine the likelihood of cancer growing back in the throat or in the neck two years after completion of radiation if lower doses of radiation are used to a smaller area of the head and neck region than is currently used in standard of care.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 150 (actual)
- First submitted
- 29 Oct 2018
- Start date
- 11 Oct 2018
- Primary completion date
- 15 Jul 2026
- Lead sponsor
- Abramson Cancer Center at Penn Medicine
- Diseases
- Head and neck cancer
- NCT number
- NCT03729518
What you commit to
- Study type: Interventional
- Participants enrolled: 150
- From 11 Oct 2018 to the primary completion date, 15 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior radiation therapy to the head and neck
Other illness
- Presence of T4 disease
- Presence of N2c or N3 neck disease (per AJCC 7th Ed)
- Presence of distant metastatic disease
Other
- \>= 5 lymph nodes
Who the study is looking for
- Patients \>= 18 years old
- Histologically confirmed diagnosis of squamous cell carcinoma of the oropharynx, p16-positive on immunohistochemistry
- Pathologic T0 (unknown primary), T1, T2, or T3 disease (per AJCC 7th Ed)
- Pathologic N0, N1, N2a, or N2b disease (per AJCC 7th Ed), with \< 5 positive lymph nodes
- ECOG Performance Status 0-1
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.