NCT03737825Completed
Computerized Cognitive Training in MS
Computerized Cognitive Training for Patients With Cognitive Deficits Due to Multiple Sclerosis: a Pilot Study
Source: ClinicalTrials.gov · Last updated 6 Apr 2026
Brief summary (registry, in English)
WHO: 40 participants with a confirmed diagnosis of Multiple Sclerosis (MS) able to engage in moderate physical activity. WHY: The purpose of this study is to evaluate two computerized brain training tools, which include light physical activity, to see if they can help improve cognitive functions, such as memory and attention, for patients with MS. WHAT: Complete a set of tests (physical and cognitive) at baseline, wear a Fitbit Flex device at home for the duration of the study, 3 supervised sessions for 4 weeks at UCSF, one visit for physical and cognitive tests at one week after the final supervised session, and one final visit 6 months after the final supervised session. WHERE: 20 participants at the UCSF Weill Institute for Neurosciences (675 Nelson Rising Lane, San Francisco, CA); 20 participants at Lausanne University Hospital (Rue du Bugnon 46, 1005 Lausanne, Switzerland)
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 2 (actual)
- First submitted
- 6 Nov 2018
- Start date
- 25 Apr 2019
- Primary completion date
- 12 Feb 2025
- Lead sponsor
- University of California, San Francisco
- Diseases
- Multiple sclerosis
- NCT number
- NCT03737825
What you commit to
- Study type: Interventional
- Participants enrolled: 2
- From 25 Apr 2019 to the primary completion date, 12 Feb 2025
- 2 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Psychiatric co-morbidity or anti-depressive or anxiolytic medication that has been changed over the 6 months preceding consideration for study enrollment
- Presence of clinically and/or radiologically confirmed relapses or disease progression in the past 12 weeks.
Other
- Falls in the past 12 weeks as evaluated in the enrollment interview \[Hopkins Falls Grading Scale (Grade \>1)\]
- Strong risk of falling, assessed using the miniBEST (score\< 16)
- Colorblindness
- Visual, mental, motor or brainstem Functional Systems Score (FSS) on the Expanded Disability Status Scale (EDSS) superior to 2.
Who the study is looking for
- Age between 18 and 60 years
- Presence of subjective cognitive complain from patient
- Objective general cognitive impairment: paper-and-pencil Symbol Digit Modalities Test (SDMT) z-score \< -0.5 at screening
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Lausanne University Hospital (CHUV) Coordinator of this site? Confirm its status | Lausanne | Switzerland | Unknown status |
| Weill Institute for Neurosciences, University of California, San Francisco Coordinator of this site? Confirm its status | San Francisco | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.