NCT03739073Completed
Can we Predict COronary Resistance By EYE Examination ? (COREYE)
Can we Predict COronary Resistance By EYE Examination ?
Source: ClinicalTrials.gov · Last updated 19 Dec 2025
Brief summary (registry, in English)
Prospective interventional study, open, non-comparative and non-randomized. The research concerns physiological parameters of the coronary and ocular blood circulation. At the coronary level, the curves of pressure and Doppler flow will be extracted from ComboMap® (Philips). The coronary microvascular resistances, basal and hyperemic, will be determined by the average ratio of the distal pressure and flow. At the ocular level, a fundus oculi and an OCTA (angiography by tomography in optical coherence) examination will be performed. The measures of the FFR and the coronary microvascular resistance will be determined by a guidewire allowing measures of pressure and by a guidewire allowing measures of Doppler flow (ComboWire®, Volcano), in 123 patients with intermediate stenosis of the left anterior descending artery (LDA). Topological parameters characterizing the retinal area and choriocapillaries will be determined by statistical approaches and mathematical morphology. To establish a predictor of the coronary microvascular resistance from the eye vascular parameters, we shall use a non-linear regression by supervised machine learning. The main cardiovascular risk factors (hypertension, diabetes, dyslipidemia, age, sex) will be part of predetermined input features for the machine learning.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 101 (actual)
- First submitted
- 5 Nov 2018
- Start date
- 4 Oct 2018
- Primary completion date
- 20 Mar 2024
- Lead sponsor
- Hospices Civils de Lyon
- Diseases
- Coronary artery disease
- NCT number
- NCT03739073
What you commit to
- Study type: Interventional
- Participants enrolled: 101
- From 4 Oct 2018 to the primary completion date, 20 Mar 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Aortocoronary bypass surgery.
Other illness
- Unstable Coronary Artery Disease
- History of myocardial infarction \<6 months in the territory of the proximal and / or mean IVA.
- Allergy to iodine, severe renal insufficiency.
- History of retinal ocular pathologies other than uncomplicated diabetic retinopathy and hypertensive retinopathy.
- History of ophthalmic treatments such as macular or panretinal laser photocoagulation, intravitreal injection of anti-VEGF or cortisone.
Other
- Atrial fibrillation
- Asthma
- Collateral development at the level of the proximal and / or mean IVA.
- Ametropia\> = 6 diopters.
- Chronic glaucoma
- Patients under guardianship or curators.
- Pregnant or lactating women.
- Patient's not affiliated to the French social security.
- Persons placed under the protection of justice,
- Subject participating in another research including an exclusion period still in progress at pre-inclusion
Who the study is looking for
- Male and female patient's ≥18 years of age with coronary arterial indication as usual and with proximal and / or mean IVA stenosis ≥ 50%.
- Signed informed consent
- Affiliation to the social security system
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospices Civils de Lyon - Hôpital de la Croix Rousse Coordinator of this site? Confirm its status | Lyon | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.