NCT03739814RecruitingPhase 2
Inotuzumab Ozogamicin and Blinatumomab With or Without Ponatinib in Treating Patients With Newly Diagnosed, Recurrent, or Refractory CD22-Positive B-Lineage Acute Lymphoblastic Leukemia
A Phase II Study of Inotuzumab Ozogamicin Followed by Blinatumomab for Ph-Negative, CD22-Positive B-Lineage Acute Lymphoblastic Leukemia in Newly Diagnosed Older Adults or Adults With Relapsed or Refractory Disease
Source: ClinicalTrials.gov · Last updated 28 Oct 2026
Brief summary (registry, in English)
This phase II trial studies how well inotuzumab ozogamicin and blinatumomab with or without ponatinib work in treating patients with CD22-positive B-lineage acute lymphoblastic leukemia that is newly diagnosed, has come back after a period of improvement (recurrent), or does not respond to treatment (refractory). Inotuzumab ozogamicin is a monoclonal antibody, called inotuzumab, linked to a chemotherapy drug, called ozogamicin. Inotuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of cancer cells, known as CD22 receptors, and delivers ozogamicin to kill them. Blinatumomab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Ponatinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving inotuzumab ozogamicin and blinatumomab with or without ponatinib may be effective in treating patients with newly diagnosed, recurrent or refractory CD22 positive B-lineage acute lymphoblastic leukemia.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 84 (estimated)
- First submitted
- 12 Nov 2018
- Start date
- 8 May 2019
- Primary completion date
- 1 Feb 2027
- Lead sponsor
- National Cancer Institute (NCI)
- Diseases
- Acute lymphoblastic leukaemia
- NCT number
- NCT03739814
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 84
- From 8 May 2019 to the primary completion date, 1 Feb 2027
- 285 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- STEP 0: Submission of bone marrow aspirate and peripheral blood for MRD analysis is mandatory prior to registration; the bone marrow sample should be from the first aspiration (i.e. first pull). Aspirate needle should be redirected if needed to get first pull bone marrow aspirate. It should be initiated as soon as possible after pre-registration. The specimens should be sent to the HEME Biobank.
- Lumbar Puncture (Spinal Tap) and Intrathecal Methotrexate:
- Patients may receive the day 1 of course IA dose of intrathecal (IT) methotrexate during the prior-to-registration lumbar puncture (or the venous line placement) to avoid a second lumbar puncture. If the dose is administered prior to registration, then systemic chemotherapy must begin within 7 days of this IT chemotherapy.
- STEP 1: Morphologic diagnosis of precursor B-cell acute lymphoblastic leukemia (ALL) based on World Health Organization (WHO) criteria. Patients with Burkitt lymphoma/leukemia are not eligible.
- STEP 1: CD22-positive disease defined as CD22 expression by \>= 20% of lymphoblasts by local hematopathology evaluation.
- STEP 1: Philadelphia chromosome/BCR-ABL1-negative or Philadelphia chromosome/BCR-ABL1-positive B-cell ALL by cytogenetics, fluorescence in situ hybridization (FISH), and/or polymerase chain reaction (PCR).
- STEP 1: No active central nervous system (CNS) leukemia (i.e. only CNS-1 disease allowed). Active CNS leukemia is defined as morphologic evidence of lymphoblasts in the cerebrospinal fluid (CSF), use of CNS-directed local treatment for active disease within 28 days prior to registration, symptomatic CNS leukemia (i.e. cranial nerve palsies or other significant neurological dysfunction) within the 28 days prior to registration, and/or known asymptomatic parenchymal CNS mass lesions; see below for additional guidance. Prophylactic intrathecal medication alone is not an exclusion.
- Categories of CNS Involvement for CNS Evaluation Prior to Registration:
- CNS 1: CSF has \< 5 WBC/uL with cytospin negative for blasts; or \>= 10 red blood cell (RBC)/uL with cytospin negative for blasts.
- CNS 2: CSF has \< 5 WBC/uL with cytospin positive for blasts; or \>= 10 RBC/uL with cytospin positive for blasts; or \>= 10 RBC/uL, WBC/uL \>= 5 but less than Steinherz/Bleyer algorithm with cytospin positive for blasts (see below).
- CNS 3: CSF has \>= 5 WBC/uL with cytospin positive for blasts; or \>= 10 RBC/uL, \>= 5 WBC/uL and positive by Steinherz/Bleyer algorithm (see below); or clinical signs of CNS leukemia (such as facial nerve palsy, brain/eye involvement or hypothalamic syndrome). Steinherz/Bleyer Method of Evaluating Initial Traumatic Lumbar Punctures:
- If the patient has leukemia cells in the peripheral blood and the lumbar puncture is traumatic and contains \>= 5 WBC/uL with blasts, the following algorithm should be used to define CNS disease: CSF WBC/CSF RBC \> 2 x (Blood WBC/Blood RBC count)
- STEP 1: Patients with known or suspected testicular involvement by leukemia are allowed provided that the patient receives concomitant scrotal/testicular radiotherapy.
- Unilateral or bilateral testicular enlargement should be assessed by ultrasound or other imaging technique. Biopsy is recommended if clinical findings are equivocal or suggestive of hydrocele or a non-leukemic mass, but further assessments are per treating physician discretion.
- STEP 1: Not pregnant and not nursing.
- This study involves agents that have known genotoxic, mutagenic, and teratogenic effects. Therefore, for women of childbearing potential only, a negative pregnancy test done =\< 7 days prior to registration is required.
- STEP 1: Eastern Cooperative Oncology Group (ECOG) performance status: 0-2
- STEP 1: No unstable cardiac disease such as myocardial infarction, angina pectoris, uncontrolled heart failure, or uncontrolled cardiac arrhythmia within 6 months of registration.
- STEP 1: No impaired cardiac function, defined as left ventricular ejection fraction (LVEF) \< 45% or New York Heart Association (NYHA) stage III or IV congestive heart failure (CHF).
- STEP 1: Patients with known human immunodeficiency virus (HIV) infection are eligible if they have been on effective antiretroviral therapy with an undetectable viral load tested within 6 months of registration.
- STEP 1: Patients with hepatitis B virus (HBV) are eligible only if they meet all the following:
- On HBV-suppressive therapy.
- No evidence of active virus.
- No evidence of HBV-related liver damage.
- STEP 1: Patients with hepatitis C virus (HCV) are eligible only if they meet all the following:
- Successfully completed complete-eradication therapy with undetectable viral load.
- No evidence of HCV-related liver damage.
- STEP 1: No history of clinically relevant neurologic disorder such as epilepsy, seizure, aphasia, stroke, severe brain injury, structural brain abnormality, benign brain tumor, dementia, Parkinson's disease, movement disorder, cerebellar disease, or other significant CNS abnormalities.
- STEP 1: No prior additional malignancy (i.e. in addition to ALL) except adequately treated basal- or squamous-cell skin cancer, in situ cervical cancer, stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease-free for \>= 2 years.
- STEP 1: No history of clinically significant ventricular arrhythmia, unexplained non-vasovagal syncope, or chronic bradycardic states such as sinoatrial block or higher degree of atrioventricular block unless a permanent pacemaker has been implanted.
- STEP 1: No history of chronic liver disease, including cirrhosis.
- STEP 1: No history of sinusoidal occlusion syndrome/veno-occlusive disease of the liver.
- STEP 1: No uncontrolled infection or recent history (within 4 months prior to registration) of deep tissue infections such as fasciitis or osteomyelitis.
- STEP 1: Total bilirubin, serum =\< 1.5 x upper limit of normal (ULN)\*
- Except in the event of: 1) Gilbert disease, in which case total bilirubin must be =\< 2 x ULN, or 2) elevated bilirubin believed by investigator to be due to leukemic infiltration, in which case total bilirubin must be =\< 2 x ULN.
- STEP 1: Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =\< 2.5 x ULN
- STEP 1: Creatinine, serum =\< 1.5 ULN OR creatinine clearance \>= 40 mL/min
- STEP 1: QT interval by Fridericia's correction formula (QTcF) =\< 470 msec
- COHORT 1: Age \>= 60 years.
- COHORT 1: Diagnosis of Philadelphia chromosome/BCR-ABL1-negative B-cell ALL.
- COHORT 1: No prior treatment for ALL except a single dose of intrathecal chemotherapy, corticosteroids, hydroxyurea, and/or leukapheresis to reduce peripheral blast count and prevent ALL complications. Allowed therapy may be administered for no more than 14 days and must be completed \>= 24 hours prior to the initiation of protocol therapy.
- COHORT 1: No plan for allogeneic or autologous hematopoietic cell transplantation (HCT).
- COHORT 2: Age \>= 18 years.
- COHORT 2: Diagnosis of Philadelphia chromosome/BCR-ABL1-negative B-cell ALL.
- COHORT 2: Relapsed or refractory disease in salvage 1 or 2.
- COHORT 2: No isolated extramedullary relapse.
- COHORT 2: Prior allogeneic HCT permitted.
- COHORT 2: Patients with prior allogeneic HCT must have completed transplantation \>= 4 months prior to registration.
- COHORT 2: Patients with prior allogeneic HCT must have no evidence of graft-versus-host disease and must have completed immunosuppressive therapy \>= 30 days prior to registration.
- COHORT 2: Prior treatment with inotuzumab ozogamicin, blinatumomab, other CD22-directed therapy, or other CD19-directed therapy is not allowed.
- COHORT 2: Prior treatment with rituximab must be completed \>= 7 days prior to registration.
- COHORT 2: Prior treatment with other monoclonal antibodies must be completed \>= 6 weeks prior to registration.
- COHORT 2: Prior treatment for ALL must be completed \>= 14 days prior to registration with the following exceptions: intrathecal chemotherapy, hydroxyurea, corticosteroids, 6-mercaptopurine, methotrexate, vincristine, and/or leukapheresis to reduce circulating absolute lymphoblast count to =\< 10,000/uL or prevent complications related to ALL are allowed but must be completed \>= 24 hours prior to the initiation of protocol therapy.
- COHORT 2: Patients should have resolution of any acute non-hematologic toxicities of prior therapy to National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version (v)5.0 grade =\< 1.
- COHORT 2: Peripheral blood absolute lymphoblast count =\< 10,000/uL (treatment allowed as above to reduce blast count to =\< 10,000/uL)
- COHORT 3: Age ≥ 75 years OR age ≥ 18 years AND ineligible for hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (HyperCVAD) regimens
- COHORT 3: Diagnosis of Philadelphia chromosome/BCR-ABL1-positive B-cell ALL
- COHORT 3: No prior treatment for ALL except a single dose of intrathecal chemotherapy, corticosteroids, hydroxyurea, BCR-ABL1-targeted tyrosine kinase inhibitor, and/or leukapheresis to reduce peripheral blast count and prevent ALL complications. Allowed non-protocol therapy may be administered for no more than 14 days and must be completed ≥ 24 hours prior to the initiation of protocol therapy.
- COHORT 3: No chronic, strong CYP3A4 inducers
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (285)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centro Comprensivo de Cancer de UPR Coordinator of this site? Confirm its status | San Juan | Puerto Rico | Recruiting |
| San Juan City Hospital Coordinator of this site? Confirm its status | San Juan | Puerto Rico | Recruiting |
| Providence Regional Cancer System-Aberdeen Coordinator of this site? Confirm its status | Aberdeen | United States | Suspended |
| Lehigh Valley Hospital-Cedar Crest Coordinator of this site? Confirm its status | Allentown | United States | Suspended |
| OSF Saint Anthony's Health Center Coordinator of this site? Confirm its status | Alton | United States | Suspended |
| Alaska Women's Cancer Care Coordinator of this site? Confirm its status | Anchorage | United States | Suspended |
| Anchorage Oncology Centre Coordinator of this site? Confirm its status | Anchorage | United States | Suspended |
| Alaska Breast Care and Surgery LLC Coordinator of this site? Confirm its status | Anchorage | United States | Suspended |
| Anchorage Associates in Radiation Medicine Coordinator of this site? Confirm its status | Anchorage | United States | Suspended |
| Katmai Oncology Group Coordinator of this site? Confirm its status | Anchorage | United States | Suspended |
| Providence Alaska Medical Center Coordinator of this site? Confirm its status | Anchorage | United States | Suspended |
| Alaska Oncology and Hematology LLC Coordinator of this site? Confirm its status | Anchorage | United States | Suspended |
| Anchorage Radiation Therapy Center Coordinator of this site? Confirm its status | Anchorage | United States | Suspended |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic Coordinator of this site? Confirm its status | Ankeny | United States | Recruiting |
| Trinity Health Saint Joseph Mercy Hospital Ann Arbor Coordinator of this site? Confirm its status | Ann Arbor | United States | Recruiting |
| PCR Oncology Coordinator of this site? Confirm its status | Arroyo Grande | United States | Suspended |
| Emory University Hospital/Winship Cancer Institute Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
| Emory Saint Joseph's Hospital Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
| Mercy Oncology and Hematology - Clayton-Clarkson Coordinator of this site? Confirm its status | Ballwin | United States | Suspended |
| University of Maryland/Greenebaum Cancer Center Coordinator of this site? Confirm its status | Baltimore | United States | Active, not recruiting |
| Overlake Medical Center Coordinator of this site? Confirm its status | Bellevue | United States | Suspended |
| PeaceHealth Saint Joseph Medical Center Coordinator of this site? Confirm its status | Bellingham | United States | Suspended |
| Saint Charles Health System Coordinator of this site? Confirm its status | Bend | United States | Suspended |
| Lehigh Valley Hospital - Muhlenberg Coordinator of this site? Confirm its status | Bethlehem | United States | Suspended |
| University of Alabama at Birmingham Cancer Center Coordinator of this site? Confirm its status | Birmingham | United States | Active, not recruiting |
| Illinois CancerCare-Bloomington Coordinator of this site? Confirm its status | Bloomington | United States | Suspended |
| Saint Luke's Cancer Institute - Boise Coordinator of this site? Confirm its status | Boise | United States | Suspended |
| Central Care Cancer Center - Bolivar Coordinator of this site? Confirm its status | Bolivar | United States | Suspended |
| Cox Cancer Center Branson Coordinator of this site? Confirm its status | Branson | United States | Suspended |
| Trinity Health Medical Center - Brighton Coordinator of this site? Confirm its status | Brighton | United States | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology - Brighton Coordinator of this site? Confirm its status | Brighton | United States | Recruiting |
| Roswell Park Cancer Institute Coordinator of this site? Confirm its status | Buffalo | United States | Active, not recruiting |
| Providence Saint Joseph Medical Center/Disney Family Cancer Center Coordinator of this site? Confirm its status | Burbank | United States | Suspended |
| Loyola Center for Health at Burr Ridge Coordinator of this site? Confirm its status | Burr Ridge | United States | Suspended |
| Illinois CancerCare-Canton Coordinator of this site? Confirm its status | Canton | United States | Suspended |
| Trinity Health IHA Medical Group Hematology Oncology - Canton Coordinator of this site? Confirm its status | Canton | United States | Recruiting |
| Trinity Health Medical Center - Canton Coordinator of this site? Confirm its status | Canton | United States | Recruiting |
| Mercy Cancer Center - Cape Girardeau Coordinator of this site? Confirm its status | Cape Girardeau | United States | Suspended |
| Saint Francis Medical Center Coordinator of this site? Confirm its status | Cape Girardeau | United States | Suspended |
| Memorial Hospital of Carbondale Coordinator of this site? Confirm its status | Carbondale | United States | Suspended |
| Caro Cancer Center Coordinator of this site? Confirm its status | Caro | United States | Suspended |
| Carson Tahoe Regional Medical Center Coordinator of this site? Confirm its status | Carson City | United States | Suspended |
| SIH Cancer Institute Coordinator of this site? Confirm its status | Carterville | United States | Suspended |
| Illinois CancerCare-Carthage Coordinator of this site? Confirm its status | Carthage | United States | Suspended |
| Centralia Oncology Clinic Coordinator of this site? Confirm its status | Centralia | United States | Suspended |
| Providence Regional Cancer System-Centralia Coordinator of this site? Confirm its status | Centralia | United States | Suspended |
| Christiana Care Health System-Concord Health Center Coordinator of this site? Confirm its status | Chadds Ford | United States | Suspended |
| UNC Lineberger Comprehensive Cancer Center Coordinator of this site? Confirm its status | Chapel Hill | United States | Suspended |
| Chelsea Hospital Coordinator of this site? Confirm its status | Chelsea | United States | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Coordinator of this site? Confirm its status | Chelsea | United States | Recruiting |
| Northwestern University Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| University of Chicago Comprehensive Cancer Center Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| University of Illinois Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| University of Cincinnati Cancer Center-UC Medical Center Coordinator of this site? Confirm its status | Cincinnati | United States | Recruiting |
| Siteman Cancer Center at Saint Peters Hospital Coordinator of this site? Confirm its status | City of Saint Peters | United States | Recruiting |
| Providence Cancer Institute Clackamas Clinic Coordinator of this site? Confirm its status | Clackamas | United States | Suspended |
| Clackamas Radiation Oncology Center Coordinator of this site? Confirm its status | Clackamas | United States | Recruiting |
| Newland Medical Associates-Clarkston Coordinator of this site? Confirm its status | Clarkston | United States | Suspended |
| Hematology Oncology Consultants-Clarkston Coordinator of this site? Confirm its status | Clarkston | United States | Suspended |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic Coordinator of this site? Confirm its status | Clive | United States | Recruiting |
| Community Cancer Institute Coordinator of this site? Confirm its status | Clovis | United States | Active, not recruiting |
| University Oncology Associates Coordinator of this site? Confirm its status | Clovis | United States | Active, not recruiting |
| Ohio State University Comprehensive Cancer Center Coordinator of this site? Confirm its status | Columbus | United States | Recruiting |
| Bay Area Hospital Coordinator of this site? Confirm its status | Coos Bay | United States | Suspended |
| Siteman Cancer Center at West County Hospital Coordinator of this site? Confirm its status | Creve Coeur | United States | Recruiting |
| Cancer Care Specialists of Illinois - Decatur Coordinator of this site? Confirm its status | Decatur | United States | Recruiting |
| Decatur Memorial Hospital Coordinator of this site? Confirm its status | Decatur | United States | Suspended |
| UI Health Care Mission Cancer and Blood - Des Moines Clinic Coordinator of this site? Confirm its status | Des Moines | United States | Recruiting |
| UI Health Care Mission Cancer and Blood - Laurel Clinic Coordinator of this site? Confirm its status | Des Moines | United States | Recruiting |
| Henry Ford Health Saint John Hospital Coordinator of this site? Confirm its status | Detroit | United States | Recruiting |
| Illinois CancerCare-Dixon Coordinator of this site? Confirm its status | Dixon | United States | Suspended |
| City of Hope Comprehensive Cancer Center Coordinator of this site? Confirm its status | Duarte | United States | Recruiting |
| Duke University Medical Center Coordinator of this site? Confirm its status | Durham | United States | Active, not recruiting |
| Henry Ford River District Hospital Coordinator of this site? Confirm its status | East China Township | United States | Recruiting |
| Pocono Medical Center Coordinator of this site? Confirm its status | East Stroudsburg | United States | Suspended |
| Marshfield Medical Center-EC Cancer Center Coordinator of this site? Confirm its status | Eau Claire | United States | Recruiting |
| Swedish Cancer Institute-Edmonds Coordinator of this site? Confirm its status | Edmonds | United States | Suspended |
| Crossroads Cancer Center Coordinator of this site? Confirm its status | Effingham | United States | Recruiting |
| Illinois CancerCare-Eureka Coordinator of this site? Confirm its status | Eureka | United States | Suspended |
| NorthShore University HealthSystem-Evanston Hospital Coordinator of this site? Confirm its status | Evanston | United States | Recruiting |
| Providence Regional Cancer Partnership Coordinator of this site? Confirm its status | Everett | United States | Suspended |
| Parkland Health Center - Farmington Coordinator of this site? Confirm its status | Farmington | United States | Suspended |
| Hurley Medical Center Coordinator of this site? Confirm its status | Flint | United States | Recruiting |
| Genesee Hematology Oncology PC Coordinator of this site? Confirm its status | Flint | United States | Suspended |
| Genesys Hurley Cancer Institute Coordinator of this site? Confirm its status | Flint | United States | Recruiting |
| Cancer Hematology Centers - Flint Coordinator of this site? Confirm its status | Flint | United States | Recruiting |
| Holy Cross Hospital Coordinator of this site? Confirm its status | Fort Lauderdale | United States | Suspended |
| Mercy Hospital Fort Smith Coordinator of this site? Confirm its status | Fort Smith | United States | Suspended |
| Saint Luke's Cancer Institute - Fruitland Coordinator of this site? Confirm its status | Fruitland | United States | Suspended |
| Western Illinois Cancer Treatment Center Coordinator of this site? Confirm its status | Galesburg | United States | Suspended |
| Illinois CancerCare-Galesburg Coordinator of this site? Confirm its status | Galesburg | United States | Suspended |
| Central Care Cancer Center - Garden City Coordinator of this site? Confirm its status | Garden City | United States | Suspended |
| NorthShore University HealthSystem-Glenbrook Hospital Coordinator of this site? Confirm its status | Glenview | United States | Recruiting |
| Central Care Cancer Center - Great Bend Coordinator of this site? Confirm its status | Great Bend | United States | Suspended |
| East Carolina University Coordinator of this site? Confirm its status | Greenville | United States | Suspended |
| Henry Ford Saint John Hospital - Van Elslander Coordinator of this site? Confirm its status | Grosse Pointe Woods | United States | Recruiting |
| Henry Ford Saint John Hospital - Academic Coordinator of this site? Confirm its status | Grosse Pointe Woods | United States | Recruiting |
| Henry Ford Saint John Hospital - Breast Coordinator of this site? Confirm its status | Grosse Pointe Woods | United States | Suspended |
| Lehigh Valley Hospital-Hazleton Coordinator of this site? Confirm its status | Hazleton | United States | Suspended |
| Las Vegas Urology - Pebble Coordinator of this site? Confirm its status | Henderson | United States | Suspended |
| Oncology Las Vegas - Henderson Coordinator of this site? Confirm its status | Henderson | United States | Suspended |
| Las Vegas Cancer Center-Henderson Coordinator of this site? Confirm its status | Henderson | United States | Suspended |
| Comprehensive Cancer Centers of Nevada - Henderson Coordinator of this site? Confirm its status | Henderson | United States | Suspended |
| Comprehensive Cancer Centers of Nevada-Horizon Ridge Coordinator of this site? Confirm its status | Henderson | United States | Suspended |
| Cancer and Blood Specialists-Henderson Coordinator of this site? Confirm its status | Henderson | United States | Suspended |
| Urology Specialists of Nevada - Green Valley Coordinator of this site? Confirm its status | Henderson | United States | Suspended |
| Comprehensive Cancer Centers of Nevada-Southeast Henderson Coordinator of this site? Confirm its status | Henderson | United States | Suspended |
| Las Vegas Urology - Green Valley Coordinator of this site? Confirm its status | Henderson | United States | Suspended |
| NorthShore University HealthSystem-Highland Park Hospital Coordinator of this site? Confirm its status | Highland Park | United States | Recruiting |
| Loyola Medicine Homer Glen Coordinator of this site? Confirm its status | Homer Glen | United States | Suspended |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care Coordinator of this site? Confirm its status | Irvine | United States | Recruiting |
| Swedish Cancer Institute-Issaquah Coordinator of this site? Confirm its status | Issaquah | United States | Suspended |
| MU Health Care Goldschmidt Cancer Center Coordinator of this site? Confirm its status | Jefferson City | United States | Suspended |
| Freeman Health System Coordinator of this site? Confirm its status | Joplin | United States | Suspended |
| Mercy Hospital Joplin Coordinator of this site? Confirm its status | Joplin | United States | Suspended |
| Jupiter Medical Center Coordinator of this site? Confirm its status | Jupiter | United States | Recruiting |
| University of Kansas Cancer Center Coordinator of this site? Confirm its status | Kansas City | United States | Recruiting |
| Kadlec Clinic Hematology and Oncology Coordinator of this site? Confirm its status | Kennewick | United States | Suspended |
| Illinois CancerCare-Kewanee Clinic Coordinator of this site? Confirm its status | Kewanee | United States | Suspended |
| Kingman Regional Medical Center Coordinator of this site? Confirm its status | Kingman | United States | Suspended |
| Providence Regional Cancer System-Lacey Coordinator of this site? Confirm its status | Lacey | United States | Suspended |
| UC San Diego Moores Cancer Center Coordinator of this site? Confirm its status | La Jolla | United States | Recruiting |
| Northwestern Medicine Lake Forest Hospital Coordinator of this site? Confirm its status | Lake Forest | United States | Active, not recruiting |
| Northwell Health/Center for Advanced Medicine Coordinator of this site? Confirm its status | Lake Success | United States | Recruiting |
| University of Michigan Health - Sparrow Lansing Coordinator of this site? Confirm its status | Lansing | United States | Suspended |
| Comprehensive Cancer Centers of Nevada - Central Valley Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| OptumCare Cancer Care at MountainView Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| HealthCare Partners Medical Group Oncology/Hematology-San Martin Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Las Vegas Urology - Pecos Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Comprehensive Cancer Centers of Nevada - Town Center Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| OptumCare Cancer Care at Fort Apache Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Las Vegas Cancer Center-Medical Center Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Comprehensive Cancer Centers of Nevada - Northwest Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Comprehensive Cancer Centers of Nevada Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| University Medical Center of Southern Nevada Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Hope Cancer Care of Nevada Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| OptumCare Cancer Care at Charleston Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Las Vegas Urology - Cathedral Rock Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Sunrise Hospital and Medical Center Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| University Cancer Center Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Las Vegas Urology - Smoke Ranch Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Summerlin Hospital Medical Center Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Ann M Wierman MD LTD Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Urology Specialists of Nevada - Southwest Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Las Vegas Prostate Cancer Center Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Urology Specialists of Nevada - Central Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Alliance for Childhood Diseases/Cure 4 the Kids Foundation Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Radiation Oncology Centers of Nevada Southeast Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Las Vegas Urology - Sunset Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Oncology Las Vegas - Tenaya Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| HealthCare Partners Medical Group Oncology/Hematology-Tenaya Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Urology Specialists of Nevada - Northwest Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Desert West Surgery Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Radiation Oncology Centers of Nevada Central Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Comprehensive Cancer Centers of Nevada-Summerlin Coordinator of this site? Confirm its status | Las Vegas | United States | Suspended |
| Beebe Medical Center Coordinator of this site? Confirm its status | Lewes | United States | Suspended |
| Hope Cancer Clinic Coordinator of this site? Confirm its status | Livonia | United States | Suspended |
| Trinity Health Saint Mary Mercy Livonia Hospital Coordinator of this site? Confirm its status | Livonia | United States | Recruiting |
| PeaceHealth Saint John Medical Center Coordinator of this site? Confirm its status | Longview | United States | Suspended |
| Illinois CancerCare-Macomb Coordinator of this site? Confirm its status | Macomb | United States | Suspended |
| Henry Ford Saint John Hospital - Macomb Medical Coordinator of this site? Confirm its status | Macomb | United States | Recruiting |
| Henry Ford Warren Hospital - Breast Macomb Coordinator of this site? Confirm its status | Macomb | United States | Suspended |
| University of Wisconsin Carbone Cancer Center - University Hospital Coordinator of this site? Confirm its status | Madison | United States | Active, not recruiting |
| University of Wisconsin Carbone Cancer Center - Eastpark Medical Center Coordinator of this site? Confirm its status | Madison | United States | Active, not recruiting |
| North Shore University Hospital Coordinator of this site? Confirm its status | Manhasset | United States | Recruiting |
| Saint Mary's Oncology/Hematology Associates of Marlette Coordinator of this site? Confirm its status | Marlette | United States | Suspended |
| Marshfield Medical Center-Marshfield Coordinator of this site? Confirm its status | Marshfield | United States | Recruiting |
| Loyola University Medical Center Coordinator of this site? Confirm its status | Maywood | United States | Recruiting |
| Marjorie Weinberg Cancer Center at Loyola-Gottlieb Coordinator of this site? Confirm its status | Melrose Park | United States | Suspended |
| Froedtert Menomonee Falls Hospital Coordinator of this site? Confirm its status | Menomonee Falls | United States | Recruiting |
| Saint Luke's Cancer Institute - Meridian Coordinator of this site? Confirm its status | Meridian | United States | Suspended |
| Beebe South Coastal Health Campus Coordinator of this site? Confirm its status | Millville | United States | Suspended |
| Medical College of Wisconsin Coordinator of this site? Confirm its status | Milwaukee | United States | Recruiting |
| Marshfield Medical Center - Minocqua Coordinator of this site? Confirm its status | Minocqua | United States | Recruiting |
| Saint Patrick Hospital - Community Hospital Coordinator of this site? Confirm its status | Missoula | United States | Suspended |
| West Virginia University Healthcare Coordinator of this site? Confirm its status | Morgantown | United States | Active, not recruiting |
| SSM Health Good Samaritan Coordinator of this site? Confirm its status | Mount Vernon | United States | Suspended |
| Saint Luke's Cancer Institute - Nampa Coordinator of this site? Confirm its status | Nampa | United States | Suspended |
| Saint Alphonsus Cancer Care Center-Nampa Coordinator of this site? Confirm its status | Nampa | United States | Recruiting |
| Helen F Graham Cancer Center Coordinator of this site? Confirm its status | Newark | United States | Recruiting |
| Christiana Care Health System-Christiana Hospital Coordinator of this site? Confirm its status | Newark | United States | Suspended |
| Medical Oncology Hematology Consultants PA Coordinator of this site? Confirm its status | Newark | United States | Recruiting |
| Delaware Clinical and Laboratory Physicians PA Coordinator of this site? Confirm its status | Newark | United States | Suspended |
| Providence Newberg Medical Center Coordinator of this site? Confirm its status | Newberg | United States | Recruiting |
| Froedtert and MCW Moorland Reserve Health Center Coordinator of this site? Confirm its status | New Berlin | United States | Recruiting |
| Long Island Jewish Medical Center Coordinator of this site? Confirm its status | New Hyde Park | United States | Recruiting |
| UC Comprehensive Cancer Center at Silver Cross Coordinator of this site? Confirm its status | New Lenox | United States | Recruiting |
| Ochsner Medical Center Jefferson Coordinator of this site? Confirm its status | New Orleans | United States | Active, not recruiting |
| NYP/Weill Cornell Medical Center Coordinator of this site? Confirm its status | New York | United States | Active, not recruiting |
| Drexel Town Square Health Center Coordinator of this site? Confirm its status | Oak Creek | United States | Recruiting |
| Cancer Care Center of O'Fallon Coordinator of this site? Confirm its status | O'Fallon | United States | Suspended |
| University of Oklahoma Health Sciences Center Coordinator of this site? Confirm its status | Oklahoma City | United States | Recruiting |
| Mercy Hospital Oklahoma City Coordinator of this site? Confirm its status | Oklahoma City | United States | Suspended |
| Nebraska Medicine-Village Pointe Coordinator of this site? Confirm its status | Omaha | United States | Active, not recruiting |
| University of Nebraska Medical Center Coordinator of this site? Confirm its status | Omaha | United States | Active, not recruiting |
| UC Irvine Health- Chao Family Comprehensive Cancer Center Coordinator of this site? Confirm its status | Orange | United States | Recruiting |
| Providence Willamette Falls Medical Center Coordinator of this site? Confirm its status | Oregon City | United States | Recruiting |
| University of Chicago Medicine-Orland Park Coordinator of this site? Confirm its status | Orland Park | United States | Recruiting |
| Illinois CancerCare-Ottawa Clinic Coordinator of this site? Confirm its status | Ottawa | United States | Suspended |
| Hope Cancer Care of Nevada-Pahrump Coordinator of this site? Confirm its status | Pahrump | United States | Suspended |
| Stanford Cancer Institute Palo Alto Coordinator of this site? Confirm its status | Palo Alto | United States | Active, not recruiting |
| OSF Saint Francis Radiation Oncology at Pekin Coordinator of this site? Confirm its status | Pekin | United States | Suspended |
| Illinois CancerCare-Pekin Coordinator of this site? Confirm its status | Pekin | United States | Suspended |
| OSF Saint Francis Medical Center Coordinator of this site? Confirm its status | Peoria | United States | Suspended |
| Illinois CancerCare-Peoria Coordinator of this site? Confirm its status | Peoria | United States | Recruiting |
| Methodist Medical Center of Illinois Coordinator of this site? Confirm its status | Peoria | United States | Suspended |
| OSF Saint Francis Radiation Oncology at Peoria Cancer Center Coordinator of this site? Confirm its status | Peoria | United States | Suspended |
| Valley Radiation Oncology Coordinator of this site? Confirm its status | Peru | United States | Suspended |
| Illinois CancerCare-Peru Coordinator of this site? Confirm its status | Peru | United States | Suspended |
| Thomas Jefferson University Hospital Coordinator of this site? Confirm its status | Philadelphia | United States | Active, not recruiting |
| Trinity Health IHA Medical Group-Alice Gustafson Center Coordinator of this site? Confirm its status | Pontiac | United States | Suspended |
| Trinity Health Saint Joseph Mercy Oakland Hospital Coordinator of this site? Confirm its status | Pontiac | United States | Recruiting |
| Hope Cancer Center Coordinator of this site? Confirm its status | Pontiac | United States | Suspended |
| Michigan Healthcare Professionals Pontiac Coordinator of this site? Confirm its status | Pontiac | United States | Suspended |
| Providence Saint Vincent Medical Center Coordinator of this site? Confirm its status | Portland | United States | Recruiting |
| Providence Portland Medical Center Coordinator of this site? Confirm its status | Portland | United States | Recruiting |
| Oregon Health and Science University Coordinator of this site? Confirm its status | Portland | United States | Active, not recruiting |
| Illinois CancerCare-Princeton Coordinator of this site? Confirm its status | Princeton | United States | Suspended |
| Saint Charles Health System-Redmond Coordinator of this site? Confirm its status | Redmond | United States | Suspended |
| Beebe Health Campus Coordinator of this site? Confirm its status | Rehoboth Beach | United States | Suspended |
| Saint Mary's Regional Medical Center Coordinator of this site? Confirm its status | Reno | United States | Suspended |
| Radiation Oncology Associates Coordinator of this site? Confirm its status | Reno | United States | Suspended |
| Renown Regional Medical Center Coordinator of this site? Confirm its status | Reno | United States | Suspended |
| Valley Medical Center Coordinator of this site? Confirm its status | Renton | United States | Suspended |
| Marshfield Medical Center-Rice Lake Coordinator of this site? Confirm its status | Rice Lake | United States | Recruiting |
| VCU Massey Comprehensive Cancer Center Coordinator of this site? Confirm its status | Richmond | United States | Recruiting |
| University of Rochester Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
| Mayo Clinic in Rochester Coordinator of this site? Confirm its status | Rochester | United States | Completed |
| Henry Ford Rochester Hospital Coordinator of this site? Confirm its status | Rochester Hills | United States | Suspended |
| Phelps Health Delbert Day Cancer Institute Coordinator of this site? Confirm its status | Rolla | United States | Suspended |
| Mercy Clinic-Rolla-Cancer and Hematology Coordinator of this site? Confirm its status | Rolla | United States | Suspended |
| MyMichigan Medical Center Saginaw Coordinator of this site? Confirm its status | Saginaw | United States | Recruiting |
| Oncology Hematology Associates of Saginaw Valley PC Coordinator of this site? Confirm its status | Saginaw | United States | Suspended |
| Sainte Genevieve County Memorial Hospital Coordinator of this site? Confirm its status | Sainte Genevieve | United States | Suspended |
| Heartland Regional Medical Center Coordinator of this site? Confirm its status | Saint Joseph | United States | Suspended |
| TidalHealth Nanticoke / Allen Cancer Center Coordinator of this site? Confirm its status | Seaford | United States | Suspended |
| Swedish Medical Center-Ballard Campus Coordinator of this site? Confirm its status | Seattle | United States | Suspended |
| Swedish Medical Center-Cherry Hill Coordinator of this site? Confirm its status | Seattle | United States | Suspended |
| Pacific Gynecology Specialists Coordinator of this site? Confirm its status | Seattle | United States | Suspended |
| Swedish Medical Center-First Hill Coordinator of this site? Confirm its status | Seattle | United States | Suspended |
| PeaceHealth United General Medical Center Coordinator of this site? Confirm its status | Sedro-Woolley | United States | Suspended |
| Providence Regional Cancer System-Shelton Coordinator of this site? Confirm its status | Shelton | United States | Suspended |
| Mercy Medical Center Coordinator of this site? Confirm its status | Springfield | United States | Active, not recruiting |
| CoxHealth South Hospital Coordinator of this site? Confirm its status | Springfield | United States | Suspended |
| Southern Illinois University School of Medicine Coordinator of this site? Confirm its status | Springfield | United States | Suspended |
| Springfield Clinic Coordinator of this site? Confirm its status | Springfield | United States | Suspended |
| Springfield Memorial Hospital Coordinator of this site? Confirm its status | Springfield | United States | Suspended |
| Mercy Hospital Springfield Coordinator of this site? Confirm its status | Springfield | United States | Suspended |
| Bhadresh Nayak MD PC-Sterling Heights Coordinator of this site? Confirm its status | Sterling Heights | United States | Suspended |
| Marshfield Medical Center-River Region at Stevens Point Coordinator of this site? Confirm its status | Stevens Point | United States | Recruiting |
| Siteman Cancer Center at Christian Hospital Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
| Washington University School of Medicine Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
| Missouri Baptist Medical Center Coordinator of this site? Confirm its status | St Louis | United States | Suspended |
| Mercy Hospital South Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
| Siteman Cancer Center-South County Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
| Mercy Infusion Center - Chippewa Coordinator of this site? Confirm its status | St Louis | United States | Suspended |
| Mercy Hospital Saint Louis Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
| Stony Brook University Medical Center Coordinator of this site? Confirm its status | Stony Brook | United States | Recruiting |
| Missouri Baptist Sullivan Hospital Coordinator of this site? Confirm its status | Sullivan | United States | Suspended |
| MyMichigan Medical Center Tawas Coordinator of this site? Confirm its status | Tawas City | United States | Recruiting |
| Saint Luke's Cancer Institute - Twin Falls Coordinator of this site? Confirm its status | Twin Falls | United States | Suspended |
| PeaceHealth Southwest Medical Center Coordinator of this site? Confirm its status | Vancouver | United States | Suspended |
| Providence Saint Mary Regional Cancer Center Coordinator of this site? Confirm its status | Walla Walla | United States | Suspended |
| Advanced Breast Care Center PLLC Coordinator of this site? Confirm its status | Warren | United States | Suspended |
| Henry Ford Madison Heights Hospital - Breast Coordinator of this site? Confirm its status | Warren | United States | Suspended |
| Macomb Hematology Oncology PC Coordinator of this site? Confirm its status | Warren | United States | Suspended |
| Henry Ford Warren Hospital - GLCMS Coordinator of this site? Confirm its status | Warren | United States | Recruiting |
| Henry Ford Health Warren Hospital Coordinator of this site? Confirm its status | Warren | United States | Recruiting |
| Mercy Hospital Washington Coordinator of this site? Confirm its status | Washington | United States | Suspended |
| Illinois CancerCare - Washington Coordinator of this site? Confirm its status | Washington | United States | Suspended |
| MedStar Georgetown University Hospital Coordinator of this site? Confirm its status | Washington D.C. | United States | Recruiting |
| UI Health Care Mission Cancer and Blood - Waukee Clinic Coordinator of this site? Confirm its status | Waukee | United States | Recruiting |
| Froedtert West Bend Hospital/Kraemer Cancer Center Coordinator of this site? Confirm its status | West Bend | United States | Recruiting |
| Saint Mary's Oncology/Hematology Associates of West Branch Coordinator of this site? Confirm its status | West Branch | United States | Suspended |
| University of Cincinnati Cancer Center-West Chester Coordinator of this site? Confirm its status | West Chester | United States | Recruiting |
| Marshfield Medical Center - Weston Coordinator of this site? Confirm its status | Weston | United States | Recruiting |
| University of Kansas Hospital-Westwood Cancer Center Coordinator of this site? Confirm its status | Westwood | United States | Recruiting |
| Christiana Care Health System-Wilmington Hospital Coordinator of this site? Confirm its status | Wilmington | United States | Suspended |
| Wake Forest University Health Sciences Coordinator of this site? Confirm its status | Winston-Salem | United States | Recruiting |
| North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Coordinator of this site? Confirm its status | Yakima | United States | Suspended |
| Providence Regional Cancer System-Yelm Coordinator of this site? Confirm its status | Yelm | United States | Suspended |
| Huron Gastroenterology PC Coordinator of this site? Confirm its status | Ypsilanti | United States | Recruiting |
| Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Coordinator of this site? Confirm its status | Ypsilanti | United States | Recruiting |
Related publications
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This page is information, not medical advice. Discuss any trial with your doctor.