NCT03756480Active, not recruiting
Cancer Driving Mutations in Endometriosis Lesions and Development of Progesterone Resistance
Prospective Clinical Study of the Relationship Between Cancer Driving Mutations Found in Endometriotic Implants and the Development of Progesterone Resistance
Source: ClinicalTrials.gov · Last updated 14 Oct 2026
Brief summary (registry, in English)
This study will test the hypothesis that the molecular changes present in ectopic endometriosis lesions correlate with progesterone-resistant disease (using the criteria defined in this study) and are present in matched eutopic endometrium.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 135 (estimated)
- First submitted
- 27 Nov 2018
- Start date
- 1 Oct 2020
- Primary completion date
- 1 Oct 2024
- Lead sponsor
- Johns Hopkins University
- Diseases
- Endometriosis
- NCT number
- NCT03756480
What you commit to
- Study type: Observational
- Planned participants: 135
- From 1 Oct 2020 to the primary completion date, 1 Oct 2024
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of any kind of steroidal therapy including oral contraceptives, Norplant, estrogen replacement/supplemental therapy, androgens (Danazol, Cyclomen, Danocrine, testosterone) or progesterone. She may not be taking or be on Celebrex.
- Treatment with intrauterine device (IUD) or progestin-containing intrauterine device.
Other illness
- Presence of pelvic infection.
- History of cancer of the reproductive tract.
- Presence of undiagnosed uterine bleeding.
Other
- Pregnant.
- Mullerian anomalies with absence of a cervix.
Who the study is looking for
- Signed informed consent.
- Gender: female.
- Age: 18-45 years at the time of signing consent.
- Clinical or surgical diagnosis of endometriosis undergoing laparoscopy.
- Controls may not have clinical or surgical diagnosis of endometriosis.
- Regular menstrual cycles.
- BMI between 18-40 kg/m2.
- Sexually active or have had a previous vaginal exam that used a speculum.
- English speaking
Age in the registry: 18 years to 45 years · Sex: Female
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Johns Hopkins Hospital Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Vanderbilt University Medical Center Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| Yale School of Medicine Coordinator of this site? Confirm its status | New Haven | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.