NCT03768271Recruiting
APACHE Cohort (A Psoriatic Arthritis CoHort)
French Cohort on the Becoming of Recent Articular Psoriatic Rheumatism (A Psoriatic Arthritis CoHort)
Source: ClinicalTrials.gov · Last updated 27 Apr 2026
Brief summary (registry, in English)
Psoriatic arthritis (PsA) is a chronic inflammatory rheumatic disease, belonging to the wide spectrum of spondyloarthritis, but with the particularity to be associated with personal psoriasis or familial psoriasis. PsA can be a very disabling disease through progressive and irreversible joint damage. Long-term functional prognosis of patients with PsA is correlated with the presence and severity of the radiographic joint lesions of the disease. However, the proportion of patients who will develop those peripheral joint damages is not yet known and less over the factors which are associated/involved in such an aggressive pattern of the disease. Early identification of this subgroup of patients is particularly important for determining early "intensive" treatment, strict management with a Treat To Target approach, and identification of new treatments with a stronger structural effect. The main objective of this prospective 10 years cohort is to describe the 5 years structural (radiographic) severity of recent Psoriatic arthritis (PsA)with recent peripheral arthritis.Some of the secondary objectives are to describe the 10 years structural severity within those patients, and to determine the predictive factors of those 5 and 10 years radiographic lesions (genetic, environmental, clinic, therapeutic factors). APACHE will provide a unique longitudinal standardized database concerning patients with PsA with very recent peripheral arthritis. Research projects which will based on those collected data should allow to identify the mechanisms of aggressive joint damage, to highlight mew treatments targets, to better describe the burden of the disease, to test previous or develop new assessments tolls, to develop early diagnostic criteria
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 425 (estimated)
- First submitted
- 6 Dec 2018
- Start date
- 12 Feb 2020
- Primary completion date
- 1 Dec 2031
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Diseases
- Psoriasis, Psoriatic arthritis
- NCT number
- NCT03768271
What you commit to
- Study type: Observational
- Planned participants: 425
- From 12 Feb 2020 to the primary completion date, 1 Dec 2031
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Treatment or history of treatment with a biomedicine
- Patient receiving csDMARDS (methotrexate, sulfasalazine, or leflunomide) or apremilast treatment over the past year for rheumatological symptoms
- Oral steroids in the last 4 weeks, above 10 mg/d of prednisone or with modified dosage
- intravenous or intra articular steroids in the last 4 weeks
Other illness
- Cognitive, mental or psychic disorders impeding protocol accomplishment
Other
- Formal diagnostic of inflammatory rheumatism other than psoriatic arthritis
- IRM contraindication
- Difficulties with French language understanding
- Patient under tutorship or curatorship
- Pregnancy
Who the study is looking for
- Women or men aged from 18 to 65 inclusive
- First episode of peripheral arthritis in the last 12 months, authenticated by a rheumatologist
- Psoriasis diagnosed by a practitioner or family history of psoriatic arthritis (first-degree relative \[parent or sibling\] or second degree relative)
- Arthritis most likely recognized as a psoriatic arthritis by a rheumatologist (diagnostic confidence score : ≥ 7 out of 10)
- Signed informed consent form
- Affiliation to a social security system
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Henri Mondor Hospital Coordinator of this site? Confirm its status | Créteil | France | Recruiting |
| Lapeyronie Hospital Coordinator of this site? Confirm its status | Montpellier | France | Recruiting |
| Saint Joseph Hospital Coordinator of this site? Confirm its status | Paris | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.