NCT03778827Completed
A Center Based Study of Pivotal Response Treatment for Preschoolers With Autism
A Center Based Randomized Controlled Trial of Pivotal Response Treatment for Preschoolers With Autism
Source: ClinicalTrials.gov · Last updated 5 Nov 2026
Brief summary (registry, in English)
The purpose of this study is to examine the effectiveness of pivotal response training (PRT) in an intensive center-based environment to treat social communication deficits in children with autism spectrum disorder (ASD).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 75 (actual)
- First submitted
- 15 Dec 2018
- Start date
- 13 May 2019
- Primary completion date
- 28 Mar 2026
- Lead sponsor
- Stanford University
- Diseases
- Autism
- NCT number
- NCT03778827
What you commit to
- Study type: Interventional
- Participants enrolled: 75
- From 13 May 2019 to the primary completion date, 28 Mar 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous adequate trial of Pivotal Response Treatment
Other illness
- Current or lifetime diagnosis of severe psychiatric disorder (e.g., bipolar disorder, etc.)
- Presence of active medical problem (e.g., unstable seizure disorder or heart disease)
Other
- Child primary language other than English
- More than 15 hours per week of in-home applied behavior analysis (ABA).
Who the study is looking for
- Diagnosis of Autism Spectrum Disorder (ASD) based on clinical interview and Diagnostic and Statistical Manual, 5th edition (DSM-5) and confirmed using the Autism Diagnostic Interview Revised (ADI-R) and Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) or Childhood Autism Rating Scale (CARS-2); Diagnostic and Statistical Manual, 5th edition (DSM-5), and expert clinical opinion
- Boys and girls between 2 years and 3 years and 11 months
- Ability to participate in the testing procedures to the extent that valid standard scores can be obtained
- Stable treatment (e.g., applied behavior analysis (ABA), speech therapy, psychotropic medication(s) or biomedical intervention(s) for at least 1 month prior to baseline measurements with no anticipated changes during study participation
- Developmentally delayed with Mullen Scales of Early Learning (MSEL) or Developmental Profile (DP-4) composite score below 85 (1 Standard Deviation below the mean)
- Availability of at least one English-speaking parent who can consistently participate in parent training and research measures.
Age in the registry: 2 years to 3 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Stanford University School of Medicine Coordinator of this site? Confirm its status | Stanford | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.