NCT03783143Completed
Prevalence and Incidence of Lassa Virus Infection in Southern Mali
Serosurvey for Prevalence and Incidence of Lassa Virus Infection in Southern Mali
Source: ClinicalTrials.gov · Last updated 28 Aug 2026
Brief summary (registry, in English)
Background: The disease Lassa fever mostly affects people in Western Africa. It is very similar to other diseases that cause fever, like malaria and yellow fever. People get Lassa fever from mice infected with Lassa virus. It can also be spread from body fluids of people with the disease. Researchers want to learn more about this virus in Mali so they can develop better tools to diagnose and prevent it. Objective: To find out how many people in certain areas of southern Mali have ever had Lassa fever and count how many people get the disease every year. Eligibility: People ages 6 months to 99 years who live in certain areas of Mali Design: Women who are could become pregnant will have a urine pregnancy test at each visit. Participants will be asked questions about their age, if they have ever had a fever, and if they have ever seen mice in or around their home. This will take about 20 minutes. Participants will give a blood sample using a needle in a vein in the arm. Young children will give it by pricking a finger or heel with a needle. Patients with a fever illness will have a medical history and physical exam. They will give blood and nasal swabs 3 times over 21 days. Participants may be asked to come back 1 time each year for up to 3 more years to take another sample of blood and answer more questions.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 8524 (actual)
- First submitted
- 19 Dec 2018
- Start date
- 4 Dec 2020
- Primary completion date
- 25 Jul 2024
- Lead sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
- NCT number
- NCT03783143
What you commit to
- Study type: Observational
- Participants enrolled: 8524
- From 4 Dec 2020 to the primary completion date, 25 Jul 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any condition that, in the opinion of the investigator, contraindicates participation in this study, including conditions that could hinder compliance or that could place participants or study staff at increased risk.
- Pregnancy.
- Additional exclusion criteria for the clinic-based study (study 2):
- 1\. Signs or symptoms of fever-associated conditions other than LF, such as urinary tract infection, or any other infection that may cause fever.
- Co-enrollment guidelines: Participants may be co-enrolled in other studies; however, study staff should be notified of co-enrollment
Other
- General exclusion criteria:
Criteria the registry did not label
- INCLUSION CRITERIA:
- Age greater than or equal to 6 months to 99 years.
- Resident of one of the study sites for at least 3 months.
- Able to provide informed consent.
- Agrees to allow storage of samples for future research.
- Additional inclusion criteria for the cross-sectional study (study 1):
- 1\. No plans to relocate before the study end date.
- Additional inclusion criteria for the clinic-based study (study 2):
- Has fever (temperature greater than or equal to 38 degree celcius), or has had antecedent of fever for at least 2 consecutive days at the time of screening.
- One or more of the following:
- Excluded typhoid fever and and has at least 1 of the following symptoms: chest pain, sore throat, headache, muscle pain,vomiting, and diarrhea.
- Shows bleeding or facial edema.
- Does not respond to anti-malarials or antibiotics after 2 days of treatment.
- Had contact with a confirmed LF case within the last 3 weeks.
Age in the registry: 6 months to 110 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Icer/Mrtc/Fmos/Usttb Coordinator of this site? Confirm its status | Bamako | Mali | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.