NCT03790800CompletedPhase 3
Intensive Ambulance-delivered Blood Pressure Reduction in Hyper-Acute Stroke Trial
Source: ClinicalTrials.gov · Last updated 26 Mar 2025
Brief summary (registry, in English)
A multicentre, ambulance-delivered, prospective, randomized, open-label, blinded endpoint (PROBE) study to assess the effects of hyperacute intensive blood pressure (BP) lowering initiated in ambulance setting on (i) functional outcome in patients with acute stroke (ii) safety in patients with confirmed acute stroke and other conditions that were initially suspected as acute stroke (i.e. stroke mimic).
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 2425 (actual)
- First submitted
- 26 Dec 2018
- Start date
- 20 Mar 2020
- Primary completion date
- 23 Nov 2023
- Lead sponsor
- The George Institute for Global Health, China
- Diseases
- Stroke, High blood pressure
- NCT number
- NCT03790800
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 2425
- From 20 Mar 2020 to the primary completion date, 23 Nov 2023
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Severe co-morbid disease (e.g. cancer, chronic airflow disease, severe dementia,severe heart failure,pre-stroke disability\[needed help\]);
- History of epilepsy or seizure at onset;
- History of recent head injury (\<7 days);
Lab values
- Hypoglycemia(glucose\<2.8mmol/L)
Other
- Coma - no response to tactile stimuli or verbal stimuli;
Who the study is looking for
- age ≥18 years;
- Acute syndrome that is due to presumed acute stroke, defined as FAST（Face, Arm, Speech, Time） scores of ≥2 with an arm motor deficit and time ≤2 hours from last seen well;
- Systolic BP ≥150
- Able to provide brief informed consent (if a waver of consent is not approved by the ethics committee)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The George Institute for Global Health Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| The First Affliated Hospital of Chengdu Medical College Coordinator of this site? Confirm its status | Chengdu | China | Unknown status |
| Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, China Coordinator of this site? Confirm its status | Chengdu | China | Unknown status |
| Shanghai East Hospital Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.