Time Restricted Eating on Impaired Glucose Regulation(TRIG Trial)

Prior treatment

• Taking medications affecting weight or energy intake/energy expenditure in the last 6 months, including weight loss medications, antipsychotic drugs or other medications as determined by the study physician;

Other illness

• Active and uncontrolled thyroid diseases (including subjects on thyroid replacement therapy or anti-thyroid drugs) or active endocrine diseases such as Cushing's syndrome or Acromegaly at recruitment
• History of serious cardiovascular or cerebrovascular disease (angina, myocardial infarction or stroke) in the past 6 months;

Lab values

• Serious liver dysfunction or chronic kidney disease (AST or ALT \> 3 times the upper limit of normal, or eGFR\<30 ml/min/1.73 m2);

Other

• Confirmed diagnosis of DM or on hypoglycaemic treatment
• Women who are pregnant or breast-feeding at recruitment
• Patients taking glucocorticoid at recruitment
• Currently participating in weight loss programs or weight change in the past 3 months (\> 5% current body weight) ;
• Patients who cannot be followed for 24 months (due to a health situation or migration);
• Patients who are unwilling or unable to give informed consent.

• Aged ≥ 18 year
• Diagnosis of impaired glucose regulation (i.e. FG between 5.7-6.9mmol/L) +/- impaired glucose tolerance (i.e. 2-hour postprandial PG between 7.8-11.1mmol/L) confirmed by latest OGTT results within 3 months prior to recruitment
• Body mass index (BMI)of 23.0 to 45.0 kg/m2;