REperfusion With Cooling in CerebraL Acute IscheMia II

Prior treatment

• History of severe dementia and currently taking medication for cognitive impairment or behavior disorder;
• Sustained hypertension (SBP \> 185 or DBP \> 110 unable to be treated with a continuous infusion, e.g., nicardipine);
• Concurrent participation in an investigational clinical study (excluding registries) that has not completed the follow-up period or planned participation in another study within the next 3 months;

Other illness

• The patient has a known history of bleeding diathesis, coagulopathy, cryoglobulinemia, sickle cell anemia, will refuse blood transfusions or contraindication to heparin; history of genetically confirmed hypercoagulable syndrome
• End stage renal disease on hemodialysis;
• Contrast dye allergy with history of anaphylaxis, known serious sensitivity to contrast agents or any condition in which angiography is contraindicated;
• Known allergy to meperidine or buspar or dexmedetomidine;
• Baseline CT/MR evidence of multiple vascular territory acute stroke;
• Presence of Pulmonary embolism, ilio-femoral or deep vein thrombosis
• Ongoing or spontaneous atrial fibrillation indicating severe peripheral vascular disease, aortic disease, or proximal cerebrovascular disease that in the opinion of the investigator precludes access or safe endovascular treatment
• Patient has any other condition(s) or circumstance(s) that, in the judgement of the investigator, might interfere with or impact the collection of high quality data, or with the completion of follow up requirements within the study windows.
• Patient has active or symptomatic COVID-19

Lab values

• Use of warfarin with INR \> 1.7;
• Blood clinical chemistry potassium (K+) \< 2.7;

Other

• Patient arrives to the enrolling hospital intubated
• Female patients of childbearing potential who are known to be or may be pregnant;
• The patient has a height of \< 1.5 meters (4 feet 11 inches);
• Known presence of an IVC filter;
• Known to have contraindications to radiological imaging;
• Baseline CT/MR showing evidence of arterial vasculitis or dissection;
• Excessive tortuosity of cervical vessels;
• Intracranial stent in area that may impact Recanalization;
• Presence of clinical signs of sepsis
• Presence of any other serious comorbidity that would be likely to impact life expectancy to less than 6 months or limit Patient cooperation or study compliance
• Patients without a legally authorized representative to sign the consent form will be excluded.

• Age ≥18 and ≤85;
• Signs and symptoms consistent with an acute ischemic stroke with anterior circulation large vessel occlusion (M1 MCA, carotid-terminus occlusion, Tandem occlusion allowed (Extracranial ICA+carotid T or M1 MCA)) as determined by CT imaging; (i.e., hyper dense sign on non-contrast CT or CT angiogram);
• Ability to perform arterial puncture within 24 hours from symptom onset or LKN;
• ASPECT score of 6-10 on non-contrast CT of the brain if under 80 years; ASPECTS 9-10 if age 80-85;
• For transfer patients with anticipated arterial puncture greater than 6 hours from symptom onset or LKN, qualifying imaging must be performed within 2 hours prior to enrolling hospital arrival or with a newly obtained non-contrast CT scan if this time is exceeded;
• Candidate for endovascular thrombectomy therapy in accordance with best practices per AHA standard stroke guidelines meeting all labeling requirements for EVT in the trial;
• No contraindications to general anesthesia, conscious sedation or allergies to any components associated with the anticipated diagnostic or treatment procedures that cannot be treated;
• A pre-stroke mRS of 0 or 1 (Appendix 4);
• Baseline CT scan shows no hemorrhage;
• NIHSS greater than or equal to 8 (Appendix 3);
• Patient is capable of complying with study procedures and agrees to complete all required study procedures, study visits and associated activities;
• Legally authorized representative must be able to understand and give written informed consent. Patient will assent if capable. Patient may be re-consented once it is established that there is no memory loss or cognitive impairment.

Criteria the registry did not label

• All Inclusion Criteria must be answered YES for Patient to be eligible.
• Age ≥18 and ≤85;
• Signs and symptoms consistent with an acute ischemic stroke with anterior circulation large vessel occlusion (M1 MCA, carotid-terminus occlusion, Tandem occlusion allowed (Extracranial ICA+carotid T or M1 MCA)) as determined by CT imaging; (i.e., hyperdense sign on non-contrast CT or CT angiogram);
• Ability to perform arterial puncture within 24 hours from symptom onset or LKN;
• ASPECTS score of 6-10 on non-contrast CT of the brain if under 80 years; ASPECTS 9-10 if age 80-85;
• For transfer patients with anticipated arterial puncture greater than 6 hours from symptom onset or LKN, qualifying imaging must be performed within 2 hours prior to enrolling hospital arrival; or with a newly obtained non-contrast CT scan if this time is exceeded
• Candidate for endovascular thrombectomy therapy in accordance with best practices per AHA standard stroke guidelines meeting all labeling requirements for EVT in the trial;
• No contraindications to general anesthesia, conscious sedation or allergies to any components associated with the anticipated diagnostic or treatment procedures that cannot be treated;
• A pre-stroke modified Rankin Score (mRS) of 0 or 1 (Appendix 4);
• Baseline CT scan shows no hemorrhage;
• NIHSS greater than or equal to 8 (Appendix 3);
• Patient is capable of complying with study procedures and agrees to complete all required study procedures, study visits and associated activities;
• Legally authorized representative must be able to understand and give written informed consent. Patient will assent if capable. Patient may be re-consented once it is established that there is no memory loss or cognitive impairment.
  • 5.2 Exclusion Criteria In order to be eligible for participation, patients must meet all Inclusion and Exclusion Criteria.