NCT03812653Active, not recruiting
Sleep for Stroke Management and Recovery Trial
Source: ClinicalTrials.gov · Last updated 2 Feb 2026
Brief summary (registry, in English)
The purpose of this study is to determine whether treatment of obstructive sleep apnea (OSA) with positive airway pressure starting shortly after acute ischemic stroke (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after the event, and (2) improves stroke outcomes at 3 months in patients who experienced an ischemic stroke.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 3062 (estimated)
- First submitted
- 18 Jan 2019
- Start date
- 9 May 2019
- Primary completion date
- Nov 2026
- Lead sponsor
- University of Michigan
- Diseases
- Stroke
- NCT number
- NCT03812653
What you commit to
- Study type: Interventional
- Planned participants: 3062
- From 9 May 2019 to the primary completion date, Nov 2026
- 116 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- current use of positive airway pressure, or use within one month prior to stroke
- history of prior spontaneous pneumothorax or current pneumothorax
- hypotension requiring current treatment with pressors (can enroll later if this resolves)
- massive epistaxis or previous history of massive epistaxis
- cranial surgery or head trauma within the past 6 months, with known or possible CSF leak or pneumocephalus
Other illness
- severe bullous lung disease
Other
- pre-event inability to perform all of own basic ADLs
- unable to obtain informed consent from subject or legally authorized representative
- incarcerated
- known pregnancy
- current mechanical ventilation (can enroll later if this resolves) or tracheostomy
- anatomical or dermatologic anomaly that makes use of CPAP interface unfeasible
- other specific medical circumstances that conceivably, in the opinion of the site PI, could render the patient at risk of harm from use of CPAP
- recent hemicraniectomy or suboccipital craniectomy (i.e. those whose bone has not yet been replaced), or any other recent bone removal procedure for relief of intracranial pressure
- current receipt of oxygen supplementation \>4 liters per minute
- current contact, droplet, respiratory/airborne precautions
Criteria the registry did not label
- Current Inclusion Criteria, as of 6/28/2024:
- Ischemic stroke within the prior 7 days.
- NIH Stroke Scale Score ≥1 at the time of enrollment
- Previous Inclusion Criteria, prior to 6/28/2024:
- 1\. Ischemic stroke or TIA with ABCD ≥4, within prior 14 days.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (116)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of New Mexico Hospital Coordinator of this site? Confirm its status | Albuquerque | United States | Unknown status |
| Grady Memorial Hospital Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
| University of Maryland Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| St. Luke's University Hospital Bethlehem Campus Coordinator of this site? Confirm its status | Bethlehem | United States | Unknown status |
| University of Alabama Hospital Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| Tufts Medical Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Beth Israel Deaconess Medical Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| Maimonides Medical Center Coordinator of this site? Confirm its status | Brooklyn | United States | Unknown status |
| NYU Langone Brooklyn Coordinator of this site? Confirm its status | Brooklyn | United States | Unknown status |
| Buffalo General Medical Center Coordinator of this site? Confirm its status | Buffalo | United States | Unknown status |
| The University of Vermont Medical Center Main Campus Coordinator of this site? Confirm its status | Burlington | United States | Unknown status |
| Mercy San Juan Medical Center Coordinator of this site? Confirm its status | Carmichael | United States | Unknown status |
| Chandler Regional Medical Center Coordinator of this site? Confirm its status | Chandler | United States | Unknown status |
| Carolinas Medical Center Atrium Health Coordinator of this site? Confirm its status | Charlotte | United States | Unknown status |
| UVA Medical Center Coordinator of this site? Confirm its status | Charlottesville | United States | Unknown status |
| University of Illinois Hospital and Health Sciences System Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Rush University Medical Center Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| University of Chicago Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| University of Cincinnati Medical Center Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Christ Hospital Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Morton Plant Hospital Coordinator of this site? Confirm its status | Clearwater | United States | Unknown status |
| UH Cleveland Medical Center Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| Cleveland Clinic Coordinator of this site? Confirm its status | Cleveland | United States | Unknown status |
| Palmetto Health Richland Coordinator of this site? Confirm its status | Columbia | United States | Unknown status |
| OSU Wexner Medical Center Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| Carolinas Rehab Northeast Coordinator of this site? Confirm its status | Concord | United States | Unknown status |
| Baylor Scott & White Institute of Rehabilitation Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Geisinger Clinic Coordinator of this site? Confirm its status | Danville | United States | Unknown status |
| Iowa Methodist Coordinator of this site? Confirm its status | Des Moines | United States | Unknown status |
| Henry Ford Hospital Coordinator of this site? Confirm its status | Detroit | United States | Unknown status |
| Rancho Los Amigos National Rehabilitation Center Coordinator of this site? Confirm its status | Downey | United States | Unknown status |
| JFK Neuroscience Institute Coordinator of this site? Confirm its status | Edison | United States | Unknown status |
| Inova Fairfax Coordinator of this site? Confirm its status | Falls Church | United States | Unknown status |
| McLaren-Flint Coordinator of this site? Confirm its status | Flint | United States | Unknown status |
| Broward Health Coordinator of this site? Confirm its status | Fort Lauderdale | United States | Unknown status |
| UF Health Shands Hospital Coordinator of this site? Confirm its status | Gainesville | United States | Unknown status |
| St. Mary's Hospital and Medical Center Coordinator of this site? Confirm its status | Grand Junction | United States | Unknown status |
| Trinity Health Saint Mary's Coordinator of this site? Confirm its status | Grand Rapids | United States | Unknown status |
| Guilford Neurologic Associates, Inc Coordinator of this site? Confirm its status | Greensboro | United States | Unknown status |
| Greenville Memorial Hospital Coordinator of this site? Confirm its status | Greenville | United States | Unknown status |
| Hartford Hospital Coordinator of this site? Confirm its status | Hartford | United States | Unknown status |
| Penn State Milton S. Hershey Center Coordinator of this site? Confirm its status | Hershey | United States | Unknown status |
| Memorial Hermann Texas Medical Center Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| University of Iowa Hospitals and Clinics Coordinator of this site? Confirm its status | Iowa City | United States | Unknown status |
| University of Mississippi Medical Center Coordinator of this site? Confirm its status | Jackson | United States | Unknown status |
| Brooks Rehabilitation Hospital Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| UF Jacksonville Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| Bronson Methodist Hospital Coordinator of this site? Confirm its status | Kalamazoo | United States | Unknown status |
| Saint Luke's Hospital of Kansas City Coordinator of this site? Confirm its status | Kansas City | United States | Unknown status |
| Fort Sanders Regional Medical Center Coordinator of this site? Confirm its status | Knoxville | United States | Unknown status |
| Gundersen Lutheran Medical Foundation Coordinator of this site? Confirm its status | La Crosse | United States | Unknown status |
| Scripps Memorial Coordinator of this site? Confirm its status | La Jolla | United States | Unknown status |
| UCSD Health La Jolla Coordinator of this site? Confirm its status | La Jolla | United States | Unknown status |
| Cooperman Barnabas Medical Center Coordinator of this site? Confirm its status | Livingston | United States | Unknown status |
| Cedars-Sinai Medical Center Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Kaiser Permanente - Los Angeles Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Ronald Reagan UCLA Medical Center Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Norton Healthcare Coordinator of this site? Confirm its status | Louisville | United States | Unknown status |
| University of Wisconsin - University Hospital Coordinator of this site? Confirm its status | Madison | United States | Unknown status |
| North Shore University Hospital Coordinator of this site? Confirm its status | Manhasset | United States | Unknown status |
| Methodist University Coordinator of this site? Confirm its status | Memphis | United States | Unknown status |
| Jackson Memorial Hospital Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Baptist Hospital of Miami Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Doctors Medical Center of Modesto Coordinator of this site? Confirm its status | Modesto | United States | Unknown status |
| Ruby Memorial Hospital Coordinator of this site? Confirm its status | Morgantown | United States | Unknown status |
| Intermountain Medical Center Coordinator of this site? Confirm its status | Murray | United States | Unknown status |
| Hackensack Meridian Jersey Shore University Medical Center Coordinator of this site? Confirm its status | Neptune City | United States | Unknown status |
| Yale New Haven Hospital Coordinator of this site? Confirm its status | New Haven | United States | Unknown status |
| Ochsner Medical Center - Main Campus Coordinator of this site? Confirm its status | New Orleans | United States | Unknown status |
| NYU Langone -Tish Hospital Medical Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Bellevue Hospital Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| NYP Columbia University Medical Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| University of Nebraska Medical Center Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| UCLA Kaiser Fontana Coordinator of this site? Confirm its status | Ontario | United States | Unknown status |
| UC Irvine Coordinator of this site? Confirm its status | Orange | United States | Unknown status |
| OSF Saint Francis Medical Center Coordinator of this site? Confirm its status | Peoria | United States | Unknown status |
| Hospital of the University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Temple University Hospital Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Dignity Health St Joseph's Hospital and Medical Center Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| Banner-University Medical Center Phoenix Coordinator of this site? Confirm its status | Phoenix | United States | Unknown status |
| UPMC Presbyterian Hospital Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| Casa Colina Coordinator of this site? Confirm its status | Pomona | United States | Unknown status |
| Providence St. Vincent Medical Center Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
| Kaiser Redwood Coordinator of this site? Confirm its status | Redwood City | United States | Unknown status |
| Virginia Commonwealth University Coordinator of this site? Confirm its status | Richmond | United States | Unknown status |
| Strong Memorial Hospital Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Mayo Clinic Saint Marys Campus Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| UC Davis Medical Center Coordinator of this site? Confirm its status | Sacramento | United States | Unknown status |
| Saint Cloud/Centracare Health Coordinator of this site? Confirm its status | Saint Cloud | United States | Unknown status |
| University of Utah Healthcare Coordinator of this site? Confirm its status | Salt Lake City | United States | Unknown status |
| UCSD Medical Center - Hillcrest Hospital Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
| UCSF Helen Diller Medical Center at Parnassus Heights Coordinator of this site? Confirm its status | San Francisco | United States | Unknown status |
| Orange County Global Medical Center Coordinator of this site? Confirm its status | Santa Ana | United States | Unknown status |
| Sarasota Memorial Hospital Coordinator of this site? Confirm its status | Sarasota | United States | Unknown status |
| Harborview Medical Center Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| Virginia Mason Medical Center Coordinator of this site? Confirm its status | Seattle | United States | Unknown status |
| University Health Shreveport Coordinator of this site? Confirm its status | Shreveport | United States | Unknown status |
| Avera Research Institute Coordinator of this site? Confirm its status | Sioux Falls | United States | Unknown status |
| Cox Medical Center Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Memorial Medical Center Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| Staten Island University Hospital Coordinator of this site? Confirm its status | Staten Island | United States | Unknown status |
| Barnes-Jewish Hospital Coordinator of this site? Confirm its status | St Louis | United States | Unknown status |
| Olive View-UCLA Medical Center Coordinator of this site? Confirm its status | Sylmar | United States | Unknown status |
| SUNY Upstate Medical University Coordinator of this site? Confirm its status | Syracuse | United States | Unknown status |
| Tampa General Hospital Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| St. Joseph's Hospital Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| Montefiore Medical Center Coordinator of this site? Confirm its status | The Bronx | United States | Unknown status |
| TMC Healthcare Coordinator of this site? Confirm its status | Tucson | United States | Unknown status |
| Banner University Medical Center - Tucson Coordinator of this site? Confirm its status | Tucson | United States | Unknown status |
| St. John Health System Coordinator of this site? Confirm its status | Tulsa | United States | Unknown status |
| John Muir Medical Center - Walnut Creek Campus Coordinator of this site? Confirm its status | Walnut Creek | United States | Unknown status |
| George Washington University Hospital Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
| West Chester Hospital Coordinator of this site? Confirm its status | West Chester | United States | Unknown status |
| Wake Forest University Baptist Medical Center Coordinator of this site? Confirm its status | Winston-Salem | United States | Unknown status |
| Umass Memorial Medical Center Coordinator of this site? Confirm its status | Worcester | United States | Unknown status |
Related publications
- A multilevel CPAP support strategy implemented within a large stroke clinical trial (sleep SMART).Front Sleep · 2026 · PMID 42266869
This page is information, not medical advice. Discuss any trial with your doctor.