NCT03822741Recruiting
Etiology and Treatment of Neonatal Seizure
Gene Profiling and Individualized Treatment of Neonatal Seizure in China
Source: ClinicalTrials.gov · Last updated 16 Mar 2026
Brief summary (registry, in English)
Genetic diagnosis for neonates suffering from epilepsy has important implications for treatment, prognosis, and development of precision medicine strategies. Investigator performed exome sequencing (ES) or targeted sequencing on neonates with seizure onset within the first month of life. Investigator subgrouped our patients based on the onset age of seizure into neonatal and before 1 year (1-12 months), to compare the clinical and genetic features and treatment strategies.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 2000 (estimated)
- First submitted
- 2 Dec 2018
- Start date
- 8 Aug 2016
- Primary completion date
- 30 Dec 2026
- Lead sponsor
- Children's Hospital of Fudan University
- Diseases
- Epilepsy
- NCT number
- NCT03822741
What you commit to
- Study type: Observational
- Planned participants: 2000
- From 8 Aug 2016 to the primary completion date, 30 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients were excluded if they had traumas, central nervous system infections, hypoxic-ischemic encephalopathy, vascular events, systemic infections, and diagnosed metabolic disorders, and pathogenic copy-number variants were identified using array-based comparative genomic hybridization (CGH).
Who the study is looking for
- severe seizures in neonates or generalized epilepsy or intractable epilepsy in infancy with generalized tonic-clonic seizures,
- seizures onset before 1 year of age,
- epileptic syndromes/epileptic-encephalopathies with unknown etiology.
Age in the registry: - to 12 months · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Children Hospital of Fudan University Coordinator of this site? Confirm its status | Shanghai | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.