NCT03822949Recruiting
Bright Light Exposure in Surgical Patients
Bright Light Exposure in Patients Undergoing Non-cardiac Elective Surgery
Source: ClinicalTrials.gov · Last updated 14 May 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
1. Elucidate the influence of intense light therapy pretreatment in patients undergoing cardiac surgery. We hypothesize that intense light exposure is associated with the peripheral stabilization of Per2 in human buccal swabs and plasma samples before surgery and with a decrease of Troponin I levels after surgery. In addition, we hypothesize that light therapy leads to Per2 dependent metabolic optimization in the human cardiac tissue. Therefore, a small piece of human heart tissue from the right atrium will be collected during cardiac cannulation, which will be otherwise discarded. 2. Critical illness (being in the intensive care unit) results in circadian malfunction and vessels not working. Vessel function is controlled by the body's circadian clock. Intense light boosts the circadian clock and the vessel function in animal studies. Vessels not working well in critical ill patients results in a myriad of severe diseases (delirium, stroke, heart attack, organ damage etc). Thus we will test if intense light can be used to boost the circadian clock and the associated vessel function in critical ill patients.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 70 (estimated)
- First submitted
- 27 Jan 2019
- Start date
- 12 Jul 2019
- Primary completion date
- Jul 2026
- Lead sponsor
- University of Colorado, Denver
- NCT number
- NCT03822949
What you commit to
- Study type: Interventional
- Planned participants: 70
- From 12 Jul 2019 to the primary completion date, Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- participation in other clinical trials within the previous 30 days
- patients with atrial fibrillation or use of class III anti-arhythmic drug
Other illness
- neurological conditions that could impair weaning from ventilator support
- significant CNS disorders or comorbid irreversible conditions with a six-month mortality rate more than 50 percent
- medical history of type 2 diabetes
- patient in emergency condition
Lab values
- patients with a left ventricle ejection fraction \< 40%
Age
- patients \<18 or \>90 years old
Other
- pregnancy
- prisoners, or subjects with altered capabilities to make decision will be enrolled
Who the study is looking for
- Patients undergoing primary sternotomy cardiac surgery
- Subjects in the range of 18 - 90 years old .
- Patient need to be in sinus rhythm at the time of surgery.
Age in the registry: 18 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Colorado Denver | Anschutz Medical Campus Coordinator of this site? Confirm its status | Denver | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.