NCT03826771CompletedPhase 2
Post-Stroke Optimization of Walking Using Explosive Resistance
Post-Stroke Optimization of Walking Using Explosive Resistance: Concurrent Effects on Depression (POWER-D Trial)
Source: ClinicalTrials.gov · Last updated 24 Apr 2025
Brief summary (registry, in English)
The investigators will study the effects of a 12 week strength training program on individuals who have had a stroke and are depressed to see if this type of exercise training helps treat depression and improves walking function. Our goal is to use the information collected in this study to help design treatments for people who have had a stroke that will help with many of the common consequences of stroke, including depression, muscle weakness and slow walking. Progress toward overcoming some of these issues would be incredibly valuable to any person who has had a stroke and their families.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 48 (actual)
- First submitted
- 29 Jan 2019
- Start date
- 6 Feb 2019
- Primary completion date
- 15 Mar 2024
- Lead sponsor
- Medical University of South Carolina
- Diseases
- Stroke
- NCT number
- NCT03826771
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 48
- From 6 Feb 2019 to the primary completion date, 15 Mar 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Unable to ambulate at least 150 feet prior to stroke, or experienced intermittent claudication while walking
- Preexisting neurological disorders, dementia or previous stroke
Other illness
- history of congestive heart failure, unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during ADL's
- History of COPD or oxygen dependence
- History of major head trauma
- Legal blindness or severe visual impairment
- history of psychosis or other Axis I disorder that is primary
- History of DVT or pulmonary embolism within 6 months
- Uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions
- Severe hypertension with systolic \>200 mmHg and diastolic \>110 mmHg at rest
- History of seizures or currently prescribed anti-seizure medications
Other
- Life expectancy \<1 yr.
- Severe arthritis or other problems that limit passive ROM
- attempt of suicide in the last 2 years or at suicidal risk assessed by SCID interview
- Current enrollment in a clinical trial to enhance motor recovery
- Pregnancy
Who the study is looking for
- age 50-70
- stroke within the past 6 to 60 months
- residual paresis in the lower extremity (Fugl-Meyer LE motor score \<34)
- ability to walk without assistance and without an AFO during testing and training at speeds ranging from 0.2-0.8 m/s
- no antidepressant medications or no change in doses of psychotropic medication for at least 4 weeks prior to the study (6 weeks if newly initiated medication)
- HRSD question #9 regarding suicide \<2; and 7) provision of informed consent.
Age in the registry: 50 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of South Carolina Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.