NCT03836950RecruitingPhase 1/2
rTMS to Improve Cognition in Parkinson's
rTMS as a Cognitive Rehabilitation Approach in Veterans With Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 21 Apr 2026
Brief summary (registry, in English)
The purpose of this study is to examine safety, feasibility, and the behavioral and brain effects of a non-invasive treatment, repetitive transcranial magnetic stimulation (rTMS), for Veterans with Parkinson's disease or atypical parkinsonism and mild impairments in their thinking. The hypothesis is that rTMS can improve thinking for people with Parkinson's disease or atypical parkinsonism who are experiencing mild problems with their thinking ability.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 56 (estimated)
- First submitted
- 28 Jan 2019
- Start date
- 1 Apr 2020
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Parkinson disease
- NCT number
- NCT03836950
What you commit to
- Study type: Interventional · Phase 1/2
- Planned participants: 56
- From 1 Apr 2020 to the primary completion date, 31 Mar 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Cochlear implant, nerve stimulator, or intracranial metal clips
- Concurrent medication use such as tricyclic antidepressants, neuroleptic medications, any other drug known to lower seizure threshold
Other illness
- Dementia
- Failure to demonstrate decision making capacity
- History of deep brain stimulation surgery
- Has congestive heart failure
- Implanted cardiac pacemaker or defibrillator
- History of claustrophobia
- Participants at potential increased risk of seizure including those who have the following:
- history (or family history) of seizure or epilepsy
- history of stroke, head injury, or unexplained seizures
- presence of other neurological disease that may be associated with an altered seizure threshold
- such as CVA, cerebral aneurysm, dementia, increased intracranial pressure
- Secondary conditions that may significantly alter electrolyte balance or lower seizure threshold
Other
- Severe depression
- Resting head tremor
- Dyskinesia that will interfere with collecting imaging data
- Implanted medical pump
- Increased intracranial pressure
- Metal in eyes/face, shrapnel/bullet remnants in brain
- No quantifiable motor threshold such that rTMS dosage cannot be accurately deter-mined
Who the study is looking for
- Veterans who seek services at Hines VA Hospital or Jesse Brown VA Medical Center
- Diagnosis of PD or atypical parkinsonism as determined by a neurologist
- Meet criteria for having mild cognitive impairment
- Receiving stable (i.e., no changes in medication and medication dose) medication and who are expected to remain on stable medication for the duration of the RCT
- Speak and read English
- 50 years or older
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Jesse Brown VA Medical Center, Chicago, IL Coordinator of this site? Confirm its status | Chicago | United States | Not yet recruiting |
| Edward Hines Jr. VA Hospital, Hines, IL Coordinator of this site? Confirm its status | Hines | United States | Recruiting |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.