NCT03840083Recruiting
Sleep-dependent Learning in Aging
What is Sleep's Role in Alzheimer's Disease? Insight From Healthy Aging
Source: ClinicalTrials.gov · Last updated 3 Apr 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The specific objective of this proposed research is to understand whether deficits in sleep-dependent memory changes reflect age-related changes in sleep, memory, or both. The central hypothesis is that changes in both memory and sleep contribute to age-related changes in sleep-dependent memory processing. To this end, the investigators will investigate changes in learning following intervals of sleep (overnight and nap) and wake in young and older adults.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 584 (estimated)
- First submitted
- 4 Feb 2019
- Start date
- 15 Jul 2018
- Primary completion date
- 14 Jul 2025
- Lead sponsor
- University of Massachusetts, Amherst
- Diseases
- Alzheimer disease
- NCT number
- NCT03840083
What you commit to
- Study type: Interventional
- Planned participants: 584
- From 15 Jul 2018 to the primary completion date, 14 Jul 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current employment involving shift work or an inability to keep a regular sleep schedule during the week prior to testing
- Current use of psychotropic, recreational drugs, or sleep-altering medications (sleep medications, cold medicines within the past week, clonidine, sympathomimetic stimulants)
Other illness
- Past diagnosis of any sleep disorder or evidence of a sleep disorder as assessed by self-reported sleep quality assessments, a standardized diagnostic interview, and an acclimation night of polysomnography. Using acclimation-night polysomnography, participants will be excluded with an Apnea-Hypopnea Index \>15; a Period-Limb Movement in Sleep index of \>15/hr; sleep-onset latency \> 45 min (indicative of insomnia); or sleep efficiency \< 80% (see Edinger et al., Sleep, 2004). In cases in which questions arise regarding a participants' inclusion or sleep records, a practicing neurologist board-certified in sleep medicine will review the documentation.
- Past diagnosis neurological illness or head injury
- History of bipolar disorder, mania, or current evidence of depression as measured by Beck Depression Inventory score \> 25
- Diagnosis of any Axis I disorder, neurological illness or head injury (according to Demographic and Health History form);
Other
- Reported average sleep per night \< 5 or \> 9 hrs
- Daily caffeine intake of \> 4 cups (coffee, tea, colas)
- Weekly alcohol intake of \> 10 cups
- Pregnancy or \< 12 months post-partum
- Abnormal sleep (e.g., shift work, travel across \>2 time zones within the past 3 months).
- Score indicative of cognitive dysfunction (subtest scores \< 40)
- Beck Depression Scale score indicative of depression (\> 19).
- Additionally, individuals will be excluded from magnetic resonance imaging studies (Exps 1, 4) for:
- Left handed or ambidextrous
- Claustrophobia
- Presence of metal (thoroughly screened via questionnaire and metal detector)
- Pregnancy
Who the study is looking for
- Age 18-80 yrs
- Healthy sleeper
- No diagnosed sleep or neurodegenerative disorder
Age in the registry: 18 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Massachusetts Coordinator of this site? Confirm its status | Amherst | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.