NCT03842839Completed
Effect of Tiotropium on Airway Remodeling in Patients With Early Stage COPD Accessed by Optical Coherence Tomography
Source: ClinicalTrials.gov · Last updated 21 Oct 2026
Brief summary (registry, in English)
This randomized, open-label, three-arm clinical trial evaluated the effects of tiotropium on airway remodeling in patients with GOLD stage 1 COPD using endobronchial optical coherence tomography (EB-OCT). Participants were randomly assigned to receive tiotropium for 12 months followed by withdrawal for months 12-24, tiotropium continuously for 24 months, or SABA as needed without regular long-acting bronchodilator therapy. Airway morphology, pulmonary function, impulse oscillometry, and SABA use were assessed during the 24-month follow-up.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 84 (actual)
- First submitted
- 21 Jan 2019
- Start date
- 1 Aug 2019
- Primary completion date
- 7 May 2025
- Lead sponsor
- Guangzhou Institute of Respiratory Disease
- Diseases
- COPD
- NCT number
- NCT03842839
What you commit to
- Study type: Interventional
- Participants enrolled: 84
- From 1 Aug 2019 to the primary completion date, 7 May 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients have poor compliance and are unwilling to receive medication regularly.
Other illness
- Patients with other lung diseases (such as bronchiectasis, pneumothorax, pleural effusion, airway deformation, lung surgery, etc.).
Other
- Other complications of bronchoscopy or intolerance of bronchoscopy procedure.
Who the study is looking for
- Over 40 yrs; Male or female Diagnosed with COPD
- Post-bronchodilator FEV1/FVC \<0.70 and FEV1 ≥80% predicted;
- Patients must be able to perform all study related procedures
Age in the registry: 40 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University Coordinator of this site? Confirm its status | Guangzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.