NCT03848312Active, not recruitingPhase 3
Preventing Alzheimer's With Cognitive Training
Cognitive Training to Reduce Incidence of Cognitive Impairment in Older Adults
Source: ClinicalTrials.gov · Last updated 24 Aug 2026
Brief summary (registry, in English)
Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the most common form of dementia. Mild cognitive impairment is a transitional stage between normal cognitive aging and Alzheimer's disease or another type of dementia, and is indicative of higher risk for dementia. In addition to the obvious health and quality-of-life ramifications of dementia, there are high direct (e.g., subsidizing residential care needs) and indirect (e.g., lost productivity of family caregivers) economic costs. Implementing interventions to prevent MCI and dementia among older adults is of critical importance to health and maintained quality-of-life for millions of Americans. Recent data analyses from the Advanced Cognitive Training in Vital Elderly study (ACTIVE) indicate that a specific cognitive intervention, speed of processing training (SPT), significantly delays the incidence of cognitive impairment across 10 years. The primary contribution of the proposed research will be the determination of whether this cognitive training technique successfully delays the onset of clinically defined MCI or dementia across three years.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 7600 (actual)
- First submitted
- 14 Feb 2019
- Start date
- 19 Feb 2019
- Primary completion date
- 31 Jan 2028
- Lead sponsor
- University of South Florida
- Diseases
- Alzheimer disease
- NCT number
- NCT03848312
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 7600
- From 19 Feb 2019 to the primary completion date, 31 Jan 2028
- 7 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous participation in a cognitive training study
Other illness
- Self-reported diagnosis of mild cognitive impairment, dementia, stroke, traumatic brain injury, brain tumor, or a neurological disorder that affects cognition or would interfere with the ability to benefit from the study intervention (e.g., Parkinson disease, multiple sclerosis), or any other unstable medical conditions that is predisposing to imminent cognitive or functional decline (e.g., congestive heart failure, chronic obstructive pulmonary disorder dependent on oxygen, or undergoing chemotherapy or radiation).
- Self-reported use of medications typically prescribed for dementia such as: Namenda, Memantine, Namzaric, Donepezil, Aricept, Rivastigmine, Exelon, Razadyne, Galantamine, Reminyl, aducanumab, Aduhlem.
Other
- Currently enrolled in another randomized clinical trial, treatment trial, or another research study that assesses cognition
- Self-reported vision, hearing, or motor difficulties that would interfere with the ability to complete the study interventions
- Completion of 10 or more hours of a computerized cognitive training program in the last 5 years such as: Lumosity, Posit Science Brain Fitness, InSight, or Brain HQ, Lace, CogMed, CogniFit, Happy Neuron, Elevate, or Dakim
- Severe depressive symptoms (Geriatric Depression Scale score \>=5)
Who the study is looking for
- Be age 65 or older at time of consent
- Have ability to speak and understand English or Spanish
- Report adequate sensorimotor capacity to perform the computer exercises
- Report adequate visual capacity to read from a computer screen at a typical viewing distance
- Show adequate auditory capacity to understand conversational speech
- Show adequate motor capacity to touch a computer screen or control a computer mouse.
- Have no evidence of Mild Cognitive Impairment (MCI) or dementia, as assessed by the Montreal Cognitive Assessment score \>=26.
- Have adequate mental health (no self-reported diagnoses of mental illness that would interfere with ability to comply with study procedures or benefit from intervention)
- Wiling to complete all study activities
- Ability to understand study procedures and comply with them for the length of the study
Age in the registry: 65 years to - · Sex: All · Accepts healthy volunteers
Sites (7)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Duke Health Coordinator of this site? Confirm its status | Durham | United States | Unknown status |
| University of Florida Coordinator of this site? Confirm its status | Gainesville | United States | Unknown status |
| University of Florida Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| University of North Florida Coordinator of this site? Confirm its status | Jacksonville | United States | Unknown status |
| The Roskamp Institute Coordinator of this site? Confirm its status | Sarasota | United States | Unknown status |
| Clemson University Institute for Engaged Aging Coordinator of this site? Confirm its status | Seneca | United States | Unknown status |
| University of South Florida Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.