NCT03865771Recruiting
Sleep Related Memory Consolidation in Children With Age Related Focal Epilepsy.
Source: ClinicalTrials.gov · Last updated 5 Dec 2025
Brief summary (registry, in English)
Age related focal epilepsies in children encompasses, according to the ILAE criteria, benign epilepsy with centro temporal spikes (BECTS), atypical benign partial epilepsy (ABPE) and epileptic encephalopathy with continuous spike and waves during sleep (ECSWS). These non structural epilepsies are associated with interictal sleep spike and waves activated by sleep. Moreover, high prevalence of learning disorders occur in children with age related epilepsies. A correlation is suspected between learning disorders and sleep activation of spike and waves. The investigators suppose that learning dysfunction is linked to loss of information during sleep of epileptic children, unlike for control patients. As sleep allows memory consolidation of words learned during wakefulness, an epileptic activity during sleep may disrupt this consolidation, leading to a loss of information. Hypothesis: the investigators hypothesize a disruption of memory consolidation after one night in children affected with ABPE and ECSWS (severe group) compared to memory consolidation in children affected with BECTS (benign group), and control group. Primary purpose: To demonstrate that the deficit of delayed recall in 15 word learning test after one night is higher for the "severe group", compared to the "benign group" and the control group. Secondary purposes: * to study the evolution over time of memory consolidation * to evaluate the correlation of the deficit of delayed recall with executive dysfunction, clinical factors of epilepsy, neurophysiological factors of epilepsy, and sleep architecture
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 95 (estimated)
- First submitted
- 4 Mar 2019
- Start date
- 27 Mar 2019
- Primary completion date
- Sept 2027
- Lead sponsor
- University Hospital, Strasbourg, France
- Diseases
- Epilepsy
- NCT number
- NCT03865771
What you commit to
- Study type: Interventional
- Planned participants: 95
- From 27 Mar 2019 to the primary completion date, Sept 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Psychiatric trouble (DSM V) Sensorial trouble without correction Poor command of French language Minor under care
- degenerative disease
Other
- Principal:
- Specific
- Patients from "severe" and "benign" groups:
- abnormal neuroimaging
- mental deficiency
- Control group
- neurologic trouble
- abnormal sleep EEG
- intellectual deficiency
Who the study is looking for
- Principal:
- normal psychomotor development
- informed consent signed by both parents and subject if able
- affiliated to social security regimen
- Specific
- Patients from "severe" and "benign" groups:
- focal age related epilepsy: BECTS, ABPE, ECSWS (ILAE criteria)
- children hospitalized for their follow-up
- normal neuroimaging
- Control group
- -children hospitalized for a non neurologic disease
Age in the registry: 6 years to 13 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hopital D'Enfants Pediatrie Medicale Ambulatoire Coordinator of this site? Confirm its status | Nancy | France | Recruiting |
| Hopital de Hautepierre-Service de Pediatrie/Neurologie Coordinator of this site? Confirm its status | Strasbourg | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.