NCT03868150RecruitingPhase 4
Prevention of Postop Atrial Fibrillation Through Intraoperative Inducibility of Atrial Fibrillation and Amiodarone Treatment
Assessment of Intra-Operative Atrial Fibrillation Inducibility As a Screening Tool to Prevent Post-Operative Atrial Fibrillation With Prophylaxis Amiodarone
Source: ClinicalTrials.gov · Last updated 17 Feb 2026
Brief summary (registry, in English)
Patients undergoing first time cardiac surgery will undergo rapid atrial pacing prior to initiation of cardiopulmonary bypass to screen for AF inducibility. Patients with inducible AF will be randomized to prophylactic amiodarone treatment versus no treatment. Patients who are not inducible to AF will be treated with standard post-operative care. Patients will be monitored post-operatively to explore the value of intraoperative inducibility of AF to predict POAF and to evaluate whether the combination of intraoperative inducibility and precision amiodarone therapy is effective at reducing the incidence of POAF
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 600 (estimated)
- First submitted
- 6 Mar 2019
- Start date
- 1 Mar 2017
- Primary completion date
- 31 Dec 2030
- Lead sponsor
- Stanford University
- Diseases
- Atrial fibrillation
- NCT number
- NCT03868150
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 600
- From 1 Mar 2017 to the primary completion date, 31 Dec 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior surgical procedures involving heart surgery and cardiopulmonary bypass
- Any prior documented history of atrial fibrillation, atrial flutter or atrial tachycardia lasting longer than 30 seconds
- Prior history of Amiodarone treatment for the management of supraventricular tachy-arrhythmias
Other illness
- Patients requiring surgical treatment of atrial arrhythmias such as pulmonary vein isolation or Maze procedure.
Who the study is looking for
- Patients scheduled for first-time non-emergent open-heart surgery for coronary artery bypass graft (CABG) revascularization, valvular repair or replacement, combined CABG with valve repair or replacement, or valve sparing aortic root repair
- Normal sinus rhythm
- No documented history of atrial fibrillation
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Stanford University Coordinator of this site? Confirm its status | Stanford | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.