NCT03868592Recruiting
Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis
Source: ClinicalTrials.gov · Last updated 3 Mar 2026
Brief summary (registry, in English)
It is not known how much improvement in insulin regulated lipolysis (the breakdown of triglycerides) occurs following substantial, sustained weight loss. Researchers will test the effects of inflammation and lipolysis regulation in people before and after bariatric surgery (sleeve gastrectomy) to answer these questions.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 7 Mar 2019
- Start date
- 1 Aug 2019
- Primary completion date
- May 2027
- Lead sponsor
- Mayo Clinic
- Diseases
- Obesity
- NCT number
- NCT03868592
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 1 Aug 2019 to the primary completion date, May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Medications known to affect adipose tissue metabolism (e.g., beta blockers, corticosteroids)
Other illness
- Active coronary artery disease
Lab values
- Type 1 or Type 2 Diabetes diagnosis or fasting plasma glucose ≥126 mg/dL
- Renal insufficiency (serum creatinine \> 1.5mg/dl)
- Chronic active liver disease (Bilirubin \> 17mmol/L, AST \> 144 IU/L, or ALT\>165IU/L)
Other
- Participation in structured exercise (\>2 times per week for 30 minutes or longer)
- Smoking
- Pregnancy or breastfeeding.
Who the study is looking for
- BMI 40 - 50 kg/m2.
- Mo active physical illness that would interfere with mobility or weight loss after bariatric surgery
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mayo Clinic Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.