NCT03876314Completed
Physical Activity, Alzheimer's Disease and Cognition Relative to APOE Genotype
The Effect of Physical Activity on Cognition Relative to APOE Genotype (PAAD-2)
Source: ClinicalTrials.gov · Last updated 21 Aug 2026
Brief summary (registry, in English)
Physical activity and Alzheimer's disease (PAAD-2) is a randomized control trial that will assess the effects of exercise on middle-aged (40-65 years) cognitively normal adults who have a heightened risk of Alzheimer's disease (AD) due to family history (FH+). The investigators will also assess the extent to which this effect is moderated by apolipoprotein epsilon-4 (APOE4) carrier status, and will gather critical new experimental evidence on the use of physical activity to improve cognitive performance by persons at the greatest risk of Alzheimer's disease.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 180 (actual)
- First submitted
- 24 Jan 2019
- Start date
- 23 May 2019
- Primary completion date
- 21 Dec 2024
- Lead sponsor
- University of North Carolina, Greensboro
- Diseases
- Alzheimer disease
- NCT number
- NCT03876314
What you commit to
- Study type: Interventional
- Participants enrolled: 180
- From 23 May 2019 to the primary completion date, 21 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Meet the criteria for clinical cognitive impairment
- Unable to perform physical activity due to known cardiovascular, metabolic, or renal disease and are symptomatic or due to orthopedic limitations
- Self-report history of confounding neurologic, psychiatric, or active severe or functionally disabling neurologic or medical diseases, or any other conditions that might limit exercise or pose a danger to the patient
- Current use of medications to treat symptoms of Alzheimer's disease, that adversely affect cognition, or that impact heart rate
Other
- Meet the criteria for depression using the short form of the Center for Epidemiological Studies Depression Scale
- Traveling for an extended period (\>1 month) during the course of the study
Who the study is looking for
- Family History of Alzheimer's disease, cognitive impairment
- Able to communicate in English
- Not currently meeting recommendations for physical activity (the recommendations are to exercise 3 days/week for 30+ minutes per day for longer than 3 months)
- Willing to be randomized to either study condition
- Willing to complete all study activities for 1 year
Age in the registry: 40 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of North Carolina-Greensboro Coordinator of this site? Confirm its status | Greensboro | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.