NCT03883139Active, not recruiting
PRISM Intervention Study
Personalized, Responsive Intervention Sequences for Minimally Verbal Children With Autism
Source: ClinicalTrials.gov · Last updated 16 Jul 2026
Brief summary (registry, in English)
This research study, Personalized, Responsive Intervention Sequences for Minimally Verbal Children with Autism (PRISM), is designed to maximize language outcomes for limited-language preschoolers, thereby lowering the risk of being classified as "minimally verbal" at age 6, by empirically developing a two-stage, 20-week adaptive intervention approach in a real world community settings. If found efficacious, the adaptive intervention design will capitalize on the heterogeneity and evolving status of children with ASD by providing the best intervention (DTT, JASPER and CET) for children who need it (leading to individualized sequences of intervention), only when it is needed (potentially reducing burden on children).
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 140 (actual)
- First submitted
- 5 Mar 2019
- Start date
- 1 Mar 2021
- Primary completion date
- 17 Oct 2025
- Lead sponsor
- University of California, Los Angeles
- Diseases
- Autism
- NCT number
- NCT03883139
What you commit to
- Study type: Interventional
- Participants enrolled: 140
- From 1 Mar 2021 to the primary completion date, 17 Oct 2025
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- We will exclude children who have sensory and motor impairments (e.g., visual impairment, deaf or hard of hearing) and with known genetic syndromes (e.g., Down Syndrome).
Age
- We will not exclude on the basis of AAC exposure, but expect few will be exposed at these ages.
Who the study is looking for
- children meeting ADOS-2 criteria for ASD,
- age 36-59 months
- who have had \> 3 months early intervention/preschool (to ensure that children already have been exposed to some community interventions) and
- use \< 20 functional words (i.e., non-echoed, non-scripted).
- Additional inclusion criteria are:
- stable medication over the past 6 months, and
- nonverbal mental age of \>12 months on the Mullen Scales of Early Learning (visual reception and fine motor subscales).
Age in the registry: 36 months to 59 months · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Oregon Coordinator of this site? Confirm its status | Eugene | United States | Unknown status |
| UCLA Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| University of Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.