NCT03897777Active, not recruiting
Exercise, Hypertension, and Gut Dysbiosis in African Americans
Effects of Exercise on Hypertension and Gut Dysbiosis in African Americans
Source: ClinicalTrials.gov · Last updated 13 Apr 2026
Brief summary (registry, in English)
African Americans have the greatest burden of endothelial dysfunction and hypertension. Recently, gut microbial dysbiosis (a term that describes a poorly diverse gut microbial profile and lower short-chain fatty acid (SCFA) production) has been linked to hypertension and may be involved in the pathogenesis of hypertension in African Americans. African Americans have been reported to have lower gut SCFA and SCFA can reduce blood pressure. Exercise reduces blood pressure and improves gut dysbiosis (increases SCFA) and likely couples' improvements in gut microbial health and vascular function to reduce blood pressure. Thus, the goals of this research are to fill a critical void concerning the interaction of gut dysbiosis, hypertension, and utilizing exercise to identify gut microbial adaptations that accompany a reduction in blood pressure. The short-term implications of this work will advance the clinical communities understanding of the relationship between dysbiosis and the pathogenesis of hypertension in African Americans, while long term implications will promote identifying adaptable gut microbes associated with vascular health to aid in amending treatment strategies for hypertension.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 36 (estimated)
- First submitted
- 26 Jan 2019
- Start date
- 1 Jun 2019
- Primary completion date
- Jun 2030
- Lead sponsor
- North Carolina Agriculture & Technical State University
- Diseases
- High blood pressure
- NCT number
- NCT03897777
What you commit to
- Study type: Interventional
- Planned participants: 36
- From 1 Jun 2019 to the primary completion date, Jun 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Cancer within the previous 6 months; (11) pregnant females;
Other illness
- Uncontrolled hypertension, stroke, history of heart attack, heart disease;
- Metabolic disease (diabetes mellitus);
- Inflammatory diseases (inflammatory bowel disease(s), rheumatoid arthritis, and systemic lupus erythematosus);
- Kidney disease;
- Liver disease;
- Lung disease;
- Peripheral vascular disease;
- Taking hypertension medications or those known to affect inflammation or metabolic function (anti-inflammatories, statins, thyroid medication) in the past 1 month;
- Other conditions that would exclude vigorous exercise (\>2mV ST-segment depression or CVD signs and symptoms during the screening graded exercise test).
Other
- Diagnosed with any of the following:
- Kidney stones or gallbladder problems;
- Currently smoking;
Who the study is looking for
- Sedentary (regular aerobic exercise frequency ≤2 times per week and duration ≤20 minutes per session; sedentary profession);
- 30-50 years of age;
- Control normotensive (systolic BP: 90-120 mmHg/diastolic BP: 60-80 mmHg)
- Elevated to Stage 1 Hypertension (systolic BP: 120-129 mmHg/diastolic BP: 80-89 mmHg) and/or stage 1 hypertension (systolic BP: 130-159 mmHg/diastolic BP: 90-99 mmHg).
Age in the registry: 30 years to 50 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| North Carolina A&T State University Coordinator of this site? Confirm its status | Greensboro | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.